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1.发明申请GANGLIOSIDE ASSOCIATED RECOMBINANT ANTIBODIES AND THE USE THEREOF IN THE DIAGNOSIS AND TREATMENT OF TUMORS 有权姜黄素相关重组抗体及其在诊断和治疗肿瘤中的应用公开(公告)号：US20100297008A1
公开(公告)日：2010-11-25
申请号：US12407046
申请日：2009-03-19
申请人： Cristina Maria Mateo de Acosta Del Rio , Josefa Lombardero Valladares , Lourdes Tatiana Roque Navarro , Alejandro Lopez Requena
发明人： Cristina Maria Mateo de Acosta Del Rio , Josefa Lombardero Valladares , Lourdes Tatiana Roque Navarro , Alejandro Lopez Requena
CPC分类号： C07K16/4208 , A61K31/7032 , A61K31/739 , A61K39/0011 , A61K39/395 , A61K39/39558 , A61K39/39566 , A61K2039/505 , A61K2039/55505 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/3076 , C07K16/3084 , C07K16/4241 , C07K16/4266 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C12N5/0694 , C12N5/163 , G01N33/57415 , G01N33/577 , G01N33/686 , G01N2033/57403 , G01N2800/7028 , A61K2300/00
摘要： The present invention is related with the obtaining of modified antibodies by means of the DNA recombinant technology from the murine monoclonal antibody P3 (MAb P3) produced by the hybridoma cell line deposited under Budapest Treaty with accession number ECACC 94113026 and from its anti-idiotype murine monoclonal antibody 1E10 (MAbai 1E10) produced by the hybridoma cell line with deposit number ECACC 97112901, with the objective of achieving monoclonal antibodies which preserve the biological function of specific binding to the antigen of the original antibodies, but being at the same time less immunogenic. The chimeric antibodies of the invention contain the variable domains of the murine immunoglobulin and the constant regions of the human immunoglobulin; and those humanized, besides containing the constant regions of the human immunoglobulins, they are modified in the region of the murine frameworks (FRs) and in particular in those zones that could be in an antigenic site for the T cells, so several positions of the FRS are human as well. These antibodies can be used in the diagnosis and therapy of different types of tumors. The present invention is also related with use of the antibodies for therapeutical and diagnostic purposes.
摘要翻译： 本发明涉及通过DNA重组技术获得修饰的抗体，该重组技术由保藏在布达佩斯条约下，保藏号为ECACC 94113026的杂交瘤细胞系和由其抗独特型小鼠产生的鼠单克隆抗体P3（MAb P3） 由具有保藏号为ECACC 97112901的杂交瘤细胞系产生的单克隆抗体1E10（MAbai 1E10），其目的是获得保护与原始抗体的抗原特异性结合的生物学功能的单克隆抗体，但是同时具有更少的免疫原性 。 本发明的嵌合抗体含有鼠免疫球蛋白的可变区和人免疫球蛋白的恒定区; 除了包含人免疫球蛋白的恒定区域外，它们还在鼠骨架（FR）的区域中被修饰，特别是在可能在T细胞的抗原位点的那些区域中，因此， FRS也是人类。 这些抗体可用于诊断和治疗不同类型的肿瘤。 本发明还涉及抗体用于治疗和诊断目的的用途。
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2.发明授权Ganglioside associated recombinant antibodies and the use thereof in the treatment of tumors 有权神经节苷脂相关重组抗体及其在肿瘤治疗中的应用公开(公告)号：US08758753B2
公开(公告)日：2014-06-24
申请号：US12407046
申请日：2009-03-19
申请人： Cristina Maria Mateo De Acosta Del Rio , Josefa Lombardero Valladares , Lourdes Tatiana Roque Navarro , Alejandro Lopez Requena
发明人： Cristina Maria Mateo De Acosta Del Rio , Josefa Lombardero Valladares , Lourdes Tatiana Roque Navarro , Alejandro Lopez Requena
IPC分类号： A61K39/395 , C07K16/42 , C12N5/10 , G01N33/577 , C12N5/09 , G01N33/68 , C12N15/13 , C12N5/0781 , G01N33/574 , C12N5/16
CPC分类号： C07K16/4208 , A61K31/7032 , A61K31/739 , A61K39/0011 , A61K39/395 , A61K39/39558 , A61K39/39566 , A61K2039/505 , A61K2039/55505 , C07K16/00 , C07K16/18 , C07K16/30 , C07K16/3076 , C07K16/3084 , C07K16/4241 , C07K16/4266 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C12N5/0694 , C12N5/163 , G01N33/57415 , G01N33/577 , G01N33/686 , G01N2033/57403 , G01N2800/7028 , A61K2300/00
摘要： The present invention is related to the obtaining of modified antibodies by means of DNA recombinant technology from the murine monoclonal antibody P3 (MAb P3), produced by the hybridoma cell line deposited under Budapest Treaty with accession number ECACC 94113026, and from its anti-idiotype murine monoclonal antibody 1E10(MAbai 1E10), produced by the hybridoma cell line with deposit number ECACC 97112901, with the objective of achieving monoclonal antibodies which preserve the biological function of specifically binding the antigen of the original antibodies, but being at the same time less immunogenic. The chimeric antibodies of the invention contain the variable domains of the murine immunoglobulin and the constant regions of the human immunoglobulin; and those humanized, besides containing the constant regions of the human immunoglobulins, are modified in the murine framework regions (FRs), in particular, in those zones that could be in a T cell antigenic site, so that several positions of the FRS are human as well. These antibodies can be used in the diagnosis and therapy of different types of tumors. The present invention is also related to the use of the antibodies for therapeutic and diagnostic purposes.
摘要翻译： 本发明涉及通过DNA重组技术从鼠单克隆抗体P3（MAb P3）获得的修饰抗体，其由通过保藏号为ECACC 94113026的布达佩斯条约保藏的杂交瘤细胞系产生，并且其抗独特型 由具有保藏号ECACC 97112901的杂交瘤细胞系产生的鼠单克隆抗体1E10（MAbai 1E10），其目的是获得保持特异性结合原始抗体的抗原的生物学功能的单克隆抗体，但同时较少 免疫原性。 本发明的嵌合抗体含有鼠免疫球蛋白的可变区和人免疫球蛋白的恒定区; 并且除了含有人免疫球蛋白的恒定区域之外，人源化的那些在鼠框架区（FR），特别是在可能在T细胞抗原位点的那些区域中被修饰，使得FRS的几个位置是人 以及。 这些抗体可用于诊断和治疗不同类型的肿瘤。 本发明还涉及抗体用于治疗和诊断目的的用途。
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公开(公告)号：US20120121605A1
公开(公告)日：2012-05-17
申请号：US13264105
申请日：2010-05-03
申请人： Cristina Mateo De Acosta Del Rio , Ana Maria Vazquez Lopez , Alejandro Lopez Requena , Yuniel Fernandez Marrero , Yosdel Soto Lopez , Victor Brito Navarro
发明人： Cristina Mateo De Acosta Del Rio , Ana Maria Vazquez Lopez , Alejandro Lopez Requena , Yuniel Fernandez Marrero , Yosdel Soto Lopez , Victor Brito Navarro
IPC分类号： A61K39/395 , A61P9/10 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , G01N33/6893 , G01N2800/323
摘要： The present invention relates to the biotechnology and particularly with new products for use in human health.The present invention provides new specific monoclonal antibodies, which bind with high affinity sulfatides and sulfated proteoglycans.The anti sulfatides and anti sulfated proteoglycans antibodies disclosed in the present invention and described in the description, provide important diagnostic and therapeutic tools to act on pathological processes associated with the appearance of atherosclerotic plaques.Accordingly, the invention provides pharmaceutical compositions comprising MAbs of the invention or fragments thereof for the therapeutic and diagnostic use associated with cardiovascular diseases. Particularly, the present invention relates to the fragments derived from the MAbs that recognize sulfatides and sulfated proteoglycans, which can be used in the therapy or diagnosis of this pathology.
摘要翻译： 本发明涉及生物技术，尤其涉及用于人类健康的新产品。 本发明提供了新的特异性单克隆抗体，其与高亲和力硫酸酯和硫酸化蛋白多糖结合。 在本发明中公开并描述于本说明书中的抗硫酸酯化物和抗硫酸化蛋白多糖抗体提供了用于与动脉粥样硬化斑块出现相关的病理过程的重要诊断和治疗工具。 因此，本发明提供包含本发明MAb或其片段的用于与心血管疾病相关的治疗和诊断用途的药物组合物。 特别地，本发明涉及来自识别硫酸盐和硫酸化蛋白多糖的MAb的片段，其可用于治疗或诊断该病理学。
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4.发明授权公开(公告)号：US08470322B2
公开(公告)日：2013-06-25
申请号：US13264105
申请日：2010-05-03
申请人： Cristina Mateo De Acosta Del Rio , Ana Maria Vazquez Lopez , Alejandro Lopez Requena , Yuniel Fernandez Marrero , Yosdel Soto Lopez , Victor Brito Navarro
发明人： Cristina Mateo De Acosta Del Rio , Ana Maria Vazquez Lopez , Alejandro Lopez Requena , Yuniel Fernandez Marrero , Yosdel Soto Lopez , Victor Brito Navarro
IPC分类号： A61K39/395 , G01N33/53 , C07K16/46 , C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/24 , G01N33/6893 , G01N2800/323
摘要： The present invention relates to the biotechnology and particularly with new products for use in human health.The present invention provides new specific monoclonal antibodies, which bind with high affinity sulfatides and sulfated proteoglycans.The anti sulfatides and anti sulfated proteoglycans antibodies disclosed in the present invention and described in the description, provide important diagnostic and therapeutic tools to act on pathological processes associated with the appearance of atherosclerotic plaques.Accordingly, the invention provides pharmaceutical compositions comprising MAbs of the invention or fragments thereof for the therapeutic and diagnostic use associated with cardiovascular diseases. Particularly, the present invention relates to the fragments derived from the MAbs that recognize sulfatides and sulfated proteoglycans, which can be used in the therapy or diagnosis of this pathology.
摘要翻译： 本发明涉及生物技术，尤其涉及用于人类健康的新产品。 本发明提供了新的特异性单克隆抗体，其与高亲和力硫酸酯和硫酸化蛋白多糖结合。 在本发明中公开并描述于本说明书中的抗硫酸酯化物和抗硫酸化蛋白多糖抗体提供了用于与动脉粥样硬化斑块出现相关的病理过程的重要诊断和治疗工具。 因此，本发明提供包含本发明MAb或其片段的用于与心血管疾病相关的治疗和诊断用途的药物组合物。 特别地，本发明涉及来自识别硫酸盐和硫酸化蛋白多糖的MAb的片段，其可用于治疗或诊断该病理学。
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