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公开(公告)号：US20110027325A1
公开(公告)日：2011-02-03
申请号：US12934819
申请日：2009-03-09
申请人： Yusaku Sugiura , Akira Takahashi , Maki Hironaga , Akio Kabuto , Eiji Suzuki
发明人： Yusaku Sugiura , Akira Takahashi , Maki Hironaga , Akio Kabuto , Eiji Suzuki
CPC分类号： A61K9/7007 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K9/284 , A61K9/2853 , A61K9/2866 , A61K9/2886
摘要： An orally-administered agent according to the present invention comprises: a medicine-containing layer containing a medicine and having surfaces; collapse-controlling layers respectively provided on the surfaces of the medicine-containing layer; and gel-forming layers respectively provided on the collapse-controlling layers, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The collapse-controlling layers are constituted of a material containing a stomach-soluble material to be dissolved by being in contact with gastric juice. The orally-administered agent according to the present invention can be swallowed with ease and release the medicine in intended parts, in particular, the stomach of a living body.
摘要翻译： 根据本发明的口服制剂包括：含有药物并具有表面的含药层; 分别设置在含药层的表面上的崩溃控制层; 以及分别设置在塌陷控制层上的凝胶形成层，其中凝胶形成层通过吸收水而膨胀并凝胶化以形成凝胶。 崩解控制层由含有通过与胃液接触而溶解的胃溶性物质的材料构成。 根据本发明的口服制剂可以容易地吞咽，并释放预期部位，特别是生物体的胃中的药物。
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公开(公告)号：US20120034276A1
公开(公告)日：2012-02-09
申请号：US13258050
申请日：2010-03-24
申请人： Youichi Takano , Yusaku Sugiura
发明人： Youichi Takano , Yusaku Sugiura
IPC分类号： A61K9/00 , A61K31/4422
CPC分类号： A61K9/2893 , A61K9/284 , A61K9/2866 , A61K9/2886
摘要： A solid preparation 1 comprises a drug-containing unit 2 containing a cationic drug, and a gel-forming layer 4, containing an anionic polymer, for covering the drug-containing unit 2 and forming a gel with absorbing water, and optionally an intermediate layer 3 interposed between the drug-containing unit 2 and the gel-forming layer 4. The solid preparation 1 improves the elution property of the drug by incorporating an acidic component (such as tartaric acid or citric acid) into the intermediate layer 2 and/or the intermediate layer 3. The gel-forming layer 4 may comprise a carboxyvinyl polymer and a polyvalent metal compound. The gel-forming layer 4 may be covered with a surface layer (anti-adhesive layer) 5.
摘要翻译： 固体制剂1包含含有阳离子药物的药物含有单元2和含有阴离子聚合物的凝胶形成层4，用于覆盖含药单元2并用吸水形成凝胶，以及任选的中间层 插入药物含有单元2和凝胶形成层4之间。固体制剂1通过将酸性成分（如酒石酸或柠檬酸）掺入中间层2和/或 中间层3.凝胶形成层4可以包含羧基乙烯基聚合物和多价金属化合物。 凝胶形成层4可以用表面层（抗粘合剂层）5覆盖。
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公开(公告)号：US20100255066A1
公开(公告)日：2010-10-07
申请号：US12680331
申请日：2008-05-09
申请人： Yusaku Sugiura , Akio Kabuto
发明人： Yusaku Sugiura , Akio Kabuto
CPC分类号： A61K9/2086 , A61K9/7007 , A61K31/426
摘要： An orally-administered agent comprised of a laminated body having surface layers is provided. The laminated body comprises a medicine-containing layer containing a medicine and having surfaces; and at least one gel-forming layer provided on one of the surfaces of the medicine-containing layer as one of the surface layers of the laminated body. The at least one gel-forming layer includes a gel-forming agent to be swelled and gelatinized when absorbing a water-based liquid. A water absorption speed per 1 g of the gel-forming layer with respect to water of 37° C. is 0.5 g/(g·s) or higher. A gel fraction of the gel-forming layer is 20 mass % or more when the gel-forming layer is dipped into an aqueous solution of 0.9 mass % of sodium chloride having a temperature of 37° C.
摘要翻译： 提供由具有表层的层叠体构成的口服制剂。 层叠体包含含有药物并具有表面的含药层; 以及设置在药物含有层的一个表面上的至少一个凝胶形成层作为层叠体的表层之一。 所述至少一种凝胶形成层包括在吸收水性液体时溶胀并凝胶化的凝胶形成剂。 每1g凝胶形成层相对于37℃的水的吸水速度为0.5g /（g·s）以上。 当将凝胶形成层浸入0.9质量％的温度为37℃的氯化钠水溶液中时，凝胶形成层的凝胶分数为20质量％以上。
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4.发明申请公开(公告)号：US20100150988A1
公开(公告)日：2010-06-17
申请号：US12449989
申请日：2008-02-27
申请人： Yusaku Sugiura , Kaisuke Yanagimoto , Eiji Suzuki
发明人： Yusaku Sugiura , Kaisuke Yanagimoto , Eiji Suzuki
CPC分类号： A61K9/0056 , A61J3/078 , A61K9/7007 , Y10T156/1052
摘要： Film-like orally administered medications are provided which are less likely to be attached to the oral mucous membrane upon intake and can be easily detached therefrom even if attached thereto. A film-like orally administered medication (1) includes at least a medical-agent-containing layer (11). Convex portions are formed on at least one surface of the orally administered medication (1). The convex portions have at least one type of shape selected from among tapers, columns, hemispheres, and frustums. The medical-agent-containing layer includes a medical agent and a base substance.
摘要翻译： 提供薄膜状的口服药物，其在进入时不太可能附着于口腔粘膜，并且即使附着在其上也可容易地从其中分离。 膜状口服药物（1）至少含有含药剂层（11）。 在口服给药的药物（1）的至少一个表面上形成凸部。 凸部具有从锥形，立柱，半球和平截头体中选出的至少一种形状。 含药剂层包括药剂和基质。
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5.发明申请ANTI-ADHESIVE COMPOSITION, SOLID PREPARATION, AND PROCESS FOR PRODUCING THE SAME 审中-公开防粘组合物，固体制剂及其生产方法公开(公告)号：US20120015008A1
公开(公告)日：2012-01-19
申请号：US13257695
申请日：2010-03-24
申请人： Yusaku Sugiura , Youichi Takano
发明人： Yusaku Sugiura , Youichi Takano
IPC分类号： A61K9/00 , C08K5/1545 , C09D133/02
CPC分类号： A61K9/2893 , A61K9/284 , A61K9/2866 , A61K9/2886
摘要： An adhesion of a preparation 1 to an inner wall of an oral cavity is prevented by applying an anti-adhesive composition containing a water-soluble cellulose ether (e.g., an HPMC) and an anionic polymer (e.g., a carboxyvinyl polymer) to a gel-forming layer 4 covering a drug-containing unit 2 to form an anti-adhesive layer 5. The gel-forming layer 4 may be formed with a gel-forming agent (a carboxyvinyl polymer), a crosslinking agent, and a base material (e.g., a poly(vinyl alcohol)). An adhesive layer 3 may be interposed between the drug-containing unit 2 and the gel-forming layer 4.
摘要翻译： 通过将含有水溶性纤维素醚（例如，HPMC）和阴离子聚合物（例如羧基乙烯基聚合物）的抗粘合剂组合物施加到凝胶上来防止制剂1对口腔内壁的粘附 形成层4，覆盖含药单元2以形成防粘层5.凝胶形成层4可以由凝胶形成剂（羧基乙烯基聚合物），交联剂和基材（ 例如聚（乙烯醇））。 粘合剂层3可以介于含药单元2和凝胶形成层4之间。
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公开(公告)号：US20100126650A1
公开(公告)日：2010-05-27
申请号：US12593896
申请日：2007-12-14
申请人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
发明人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
CPC分类号： A61K9/0053 , A61J3/06 , A61K9/7007 , A61K31/426 , Y10T156/10 , Y10T156/1039 , Y10T156/1043
摘要： A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.
摘要翻译： 一种制备含有第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层作为最外层的口腔制剂的方法，药物密封在内部空间中，该内部空间通过将第一水溶胀性凝胶形成层 凝胶形成层和第二水溶胀性凝胶形成层的周边直接或经由粘合剂层，该方法包括（a）形成第一水溶胀性凝胶形成层的步骤，（b）步骤 在第一水溶胀性凝胶形成层的预定区域中形成凹部，（c）用药物填充凹部以获得含药体的步骤，（d）形成第二水的步骤 直接或经由粘合剂层使药物含有体上的不透水凝胶形成层，使得第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层结合在凹部周围，并且连续地进行 生产口服制剂 被披露。 根据上述口服制剂的制造方法，可以有效地制造药剂完全被掩蔽的口服制剂，从而能够在不引起药物的苦味和异味的情况下给药而不会导致药物劣化 热病历史，没有药物的流失，而不限制药物的添加量。
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公开(公告)号：US08303741B2
公开(公告)日：2012-11-06
申请号：US12593896
申请日：2007-12-14
申请人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
发明人： Akio Kabuto , Yusaku Sugiura , Eiji Suzuki , Hideaki Okabe
CPC分类号： A61K9/0053 , A61J3/06 , A61K9/7007 , A61K31/426 , Y10T156/10 , Y10T156/1039 , Y10T156/1043
摘要： A process for producing an oral preparation containing a first water-swellable gel-forming layer and a second water-swellable gel-forming layer as outermost layers, a medicine being sealed in an inner space formed by bonding the periphery of the first water-swellable gel-forming layer and the periphery of the second water-swellable gel-forming layer either directly or via an adhesive layer, the process including (a) a step of forming a first water-swellable gel-forming layer, (b) a step of forming a recess in a predetermined area of the first water-swellable gel-forming layer, (c) a step of filling the recess with a medicine to obtain a medicine-containing body, and (d) a step of forming a second water-swellable gel-forming layer over the medicine-containing body directly or via an adhesive layer so that the first water-swellable gel-forming layer and the second water-swellable gel-forming layer are bonded around the recess, and a process for continuously producing the oral preparation are disclosed. According to the above process for producing an oral preparation, an oral preparation in which the medicine is completely masked so that the medicine can be administered without a problem of bitterness and odor of the medicine can be efficiently produced without causing the medicine to deteriorate due to heat history, without a loss of the medicine, and without a limitation to the amount of the medicine to be added.
摘要翻译： 一种制备含有第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层作为最外层的口腔制剂的方法，药物密封在内部空间中，该内部空间通过将第一水溶胀性凝胶形成层 凝胶形成层和第二水溶胀性凝胶形成层的周边直接或经由粘合剂层，该方法包括（a）形成第一水溶胀性凝胶形成层的步骤，（b）步骤 在第一水溶胀性凝胶形成层的预定区域中形成凹部，（c）用药物填充凹部以获得含药体的步骤，（d）形成第二水的步骤 直接或经由粘合剂层使药物含有体上的不透水凝胶形成层，使得第一水溶胀性凝胶形成层和第二水溶胀性凝胶形成层结合在凹部周围，并且连续地进行 生产口服制剂 被披露。 根据上述口服制剂的制造方法，可以有效地制造药剂完全被掩蔽的口服制剂，从而能够在不引起药物的苦味和异味的情况下给药而不会导致药物劣化 热病历史，没有药物的流失，而不限制药物的添加量。
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公开(公告)号：US20120021059A1
公开(公告)日：2012-01-26
申请号：US13257400
申请日：2010-03-24
申请人： Youichi Takano , Yusaku Sugiura
发明人： Youichi Takano , Yusaku Sugiura
IPC分类号： A61K9/14
CPC分类号： A61K9/2886 , A61K9/7007
摘要： A solid preparation 1 comprises a drug-containing unit 2 containing a cationic drug, and a gel-forming layer 4, containing an anionic polymer, for covering the drug-containing unit 2 and forming a gel with absorbing water, and optionally an intermediate layer 3 interposed between the drug-containing unit 2 and the gel-forming layer 4. The solid preparation 1 improves the elution property of the drug by incorporating an electrolyte (e.g., calcium chloride) into the intermediate layer 2 and/or the intermediate layer 3. The gel-forming layer 4 may comprise a carboxyvinyl polymer and a polyvalent metal compound. The gel-forming layer 4 may be covered with a surface layer (anti-adhesive layer) 5.
摘要翻译： 固体制剂1包含含有阳离子药物的药物含有单元2和含有阴离子聚合物的凝胶形成层4，用于覆盖含药单元2并用吸水形成凝胶，以及任选的中间层 3。固体制剂1通过将电解质（例如氯化钙）并入中间层2和/或中间层3中来改善药物的洗脱性能 凝胶形成层4可以包含羧基乙烯基聚合物和多价金属化合物。 凝胶形成层4可以用表面层（抗粘合剂层）5覆盖。
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公开(公告)号：US20110182954A1
公开(公告)日：2011-07-28
申请号：US13121378
申请日：2009-09-15
申请人： Akira Takahashi , Yusaku Sugiura , Maki Hironaga , Akio Kabuto , Eiji Suzuki
发明人： Akira Takahashi , Yusaku Sugiura , Maki Hironaga , Akio Kabuto , Eiji Suzuki
IPC分类号： A61K9/00
CPC分类号： A61K9/284 , A61K9/209 , A61K9/2886
摘要： An orally-administered agent is provided. The orally-administered agent comprises an intestinal medicine-containing layer containing a medicine to be released in intestines and having surfaces; intestinal collapse-controlling layers provided directly or through an arbitrary layer on the surfaces of the intestinal medicine-containing layer, respectively, at least a part of the intestinal collapse-controlling layers being collapsed in the intestines, and each of the intestinal collapse-controlling layers having a surface opposite to the intestinal medicine-containing layer; and gel-forming layers provided directly or through an arbitrary layer on the sides of the surfaces of the intestinal collapse-controlling layers, respectively, wherein the gel-forming layers are swelled and gelatinized by absorbing water to form a gel. The intestinal collapse-controlling layers are constituted of a material containing an enteric material to be dissolved by being in contact with a body fluid in the intestines. The orally-administered agent according to the present invention can be swallowed with ease and can release a medicine at intended parts of a living body (in particular, within intestines).
摘要翻译： 提供口服制剂。 口服制剂包含肠内药物含有层，其含有要在肠中释放并具有表面的药物; 肠内崩解控制层分别直接或通过肠道药物含有层的表面上的任意层设置，至少一部分肠内崩解控制层在肠中塌陷，并且每个肠塌陷控制 具有与肠道药物含有层相反的表面的层; 以及凝胶形成层，其分别直接或通过肠崩解控制层的表面的任意层设置，其中凝胶形成层通过吸水而膨胀并凝胶化以形成凝胶。 肠内崩解控制层由含肠内物质的材料构成，通过与肠液接触而溶解肠溶性物质。 根据本发明的口服制剂可以容易地吞咽并且可以在生物体（特别是肠内）的目标部位释放药物。
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公开(公告)号：US20100278899A1
公开(公告)日：2010-11-04
申请号：US12746049
申请日：2008-12-04
申请人： Yusaku Sugiura , Akio Kabuto , Eiji Suzuki
发明人： Yusaku Sugiura , Akio Kabuto , Eiji Suzuki
CPC分类号： A61K9/0056 , A61K9/7007 , A61K47/10 , A61K47/26 , A61K47/30
摘要： An edible film to be ingested from an oral cavity of a living body to a body thereof is provided. The edible film is comprised of a laminated body consisting of a plurality of layers. The laminated body has surfaces and the plurality of layers include two surface layers forming of the surfaces of the laminated body. At least one of the two surface layers is disposed as an antiadhesive layer for preventing the edible film from adhering to an inside wall of the oral cavity by dissolving with water. This edible film is a film that it is difficult to adhere to the inside wall of the oral cavity, and even if it adheres to the inside wall, it is possible to easily peel off the edible film therefrom.
摘要翻译： 提供从活体的口腔摄取到其体内的可食用膜。 该可食用膜由多层构成的层叠体构成。 层叠体具有表面，多个层包括形成层叠体的表面的两个表面层。 两个表面层中的至少一个被设置为防粘附层，用于通过用水溶解来防止可食用膜粘附到口腔的内壁。 这种可食用膜是难以粘附到口腔内壁的膜，即使粘附在内壁上也可以容易地从其中剥离可食用膜。
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