公开(公告)号：US06423710B1

公开(公告)日：2002-07-23

申请号：US09717956

申请日：2000-11-21

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

IPC分类号： A61K31535

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

摘要翻译： 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统（CNS）病症中的用途。

公开(公告)号：US06458787B1

公开(公告)日：2002-10-01

申请号：US09847424

申请日：2001-05-02

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlacter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlacter

IPC分类号： A61K31535

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

公开(公告)号：US06258833B1

公开(公告)日：2001-07-10

申请号：US09471846

申请日：1999-12-23

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlacter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlacter

IPC分类号： A61K31415

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

摘要翻译： 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统（CNS）病症中的用途。

公开(公告)号：US07176229B2

公开(公告)日：2007-02-13

申请号：US11268374

申请日：2005-11-07

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence Edward Burgess ,  John Joseph Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence Edward Burgess ,  John Joseph Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

IPC分类号： A61K31/40 ,  A61K31/403 ,  C07D207/04

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

摘要翻译： 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统（CNS）病症中的用途。

公开(公告)号：US06998416B2

公开(公告)日：2006-02-14

申请号：US10758675

申请日：2004-01-15

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E. Burgess ,  John J. Gaudino ,  Zachary S. Jones ,  Bradley J. Newhouse ,  Stephen T. Schlachter

IPC分类号： A61K31/40

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

公开(公告)号：US06716871B2

公开(公告)日：2004-04-06

申请号：US10151202

申请日：2002-05-17

申请人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E Burgess ,  John J. Gaudino ,  Zachary S Jones ,  Bradley J Newhouse ,  Stephen T. Schlachter

发明人： Timothy J. Martins ,  Kerry W. Fowler ,  Joshua Odingo ,  Edward A. Kesicki ,  Amy Oliver ,  Laurence E Burgess ,  John J. Gaudino ,  Zachary S Jones ,  Bradley J Newhouse ,  Stephen T. Schlachter

IPC分类号： A61K3140

CPC分类号： C07D207/08 ,  A61K31/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  Y02A50/411

摘要： Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

摘要翻译： 公开了作为PDE4的有效和选择性抑制剂的新型吡咯烷化合物及其制备方法。 还公开了化合物在治疗炎性疾病和涉及细胞因子水平升高的其它疾病以及中枢神经系统（CNS）病症中的用途。