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公开(公告)号:US06747027B1
公开(公告)日:2004-06-08
申请号:US08898175
申请日:1997-07-22
申请人: Gary DeCrescenzo , Zaheer S. Abbas , John N. Freskos , Daniel P. Getman , Robert M. Heintz , Brent V. Mischke , Joseph J. McDonald
发明人: Gary DeCrescenzo , Zaheer S. Abbas , John N. Freskos , Daniel P. Getman , Robert M. Heintz , Brent V. Mischke , Joseph J. McDonald
IPC分类号: A61K314965
CPC分类号: C07D295/13 , C07C311/17 , C07C311/29 , C07C323/49 , C07D207/48 , C07D211/96 , C07D213/42 , C07D317/62 , C07D409/04
摘要: This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.
摘要翻译: 本发明涉及蛋白酶(蛋白酶)抑制剂,更具体地涉及用于基质金属蛋白酶13(MMP-13)的硫醇磺酰胺抑制剂,蛋白酶抑制剂的组合物,用于合成蛋白酶抑制剂的中间体,用于制备蛋白酶抑制剂的方法和方法 用于治疗与MMP-13相关的病理基质金属蛋白酶活性相关的病理状况。