公开(公告)号：US20140050736A1

公开(公告)日：2014-02-20

申请号：US14065679

申请日：2013-10-29

申请人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino Anselmus VAN HEEKE

发明人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino Anselmus VAN HEEKE

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

摘要翻译： 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

公开(公告)号：US20170101476A1

公开(公告)日：2017-04-13

申请号：US14751417

申请日：2015-06-26

申请人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino Anselmus VAN HEEKE

发明人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino Anselmus VAN HEEKE

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

公开(公告)号：US20130330346A1

公开(公告)日：2013-12-12

申请号：US13886530

申请日：2013-05-03

申请人： Zarin Brown ,  Michelle Bradley ,  Steven John Charlton ,  Gino Anselmus Van Heeke ,  Karen Cromie ,  Bruno Dombrecht ,  Soren Steffensen ,  Judith Baumeister ,  Marie-Paule Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

发明人： Zarin Brown ,  Michelle Bradley ,  Steven John Charlton ,  Gino Anselmus Van Heeke ,  Karen Cromie ,  Bruno Dombrecht ,  Soren Steffensen ,  Judith Baumeister ,  Marie-Paule Bouche ,  Carlo Boutton ,  Marie-Ange Buyse ,  Veerle Snoeck ,  Stephanie Staelens

IPC分类号： C07K16/46

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K16/468 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/31

摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

摘要翻译： 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

公开(公告)号：US20120183549A1

公开(公告)日：2012-07-19

申请号：US13290175

申请日：2011-11-07

申请人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino VAN HEEKE

发明人： Michelle BRADLEY ,  Zarin BROWN ,  Steven John CHARLTON ,  Karen CROMIE ,  Bruno DOMBRECHT ,  Soren STEFFENSEN ,  Gino VAN HEEKE

IPC分类号： A61K39/395 ,  C12N15/62 ,  C12N15/63 ,  C07K19/00 ,  C12N15/13 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61P11/00 ,  A61P11/06 ,  A61P9/10 ,  A61P13/12 ,  A61P1/00 ,  A61P9/00 ,  A61P27/02 ,  A61P9/12 ,  A61P29/00 ,  A61P19/02 ,  A61P35/00 ,  A61P35/04 ,  A61P7/00 ,  A61P3/10 ,  C07K16/46

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.

摘要翻译： 本发明涉及针对或特异性结合趋化因子受体CXCR2的多肽，特别涉及能够调节CXCR2信号转导的多肽。 本发明还涉及能够表达本发明多肽的核酸，载体和宿主细胞，包含多肽的药物组合物以及用于治疗涉及CXCR2异常功能的疾病的所述多肽和组合物的用途。

公开(公告)号：US08591896B2

公开(公告)日：2013-11-26

申请号：US13290175

申请日：2011-11-07

申请人： Michelle Bradley ,  Zarin Brown ,  Steven John Charlton ,  Karen Cromie ,  Bruno Dombrecht ,  Soren Steffensen ,  Gino Van Heeke

发明人： Michelle Bradley ,  Zarin Brown ,  Steven John Charlton ,  Karen Cromie ,  Bruno Dombrecht ,  Soren Steffensen ,  Gino Van Heeke

IPC分类号： A61K39/395 ,  C07K16/46 ,  C12N15/13 ,  C12N15/62 ,  C12N5/10

CPC分类号： C07K16/2866 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/626 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to polypeptides directed against or specifically binding to chemokine receptor CXCR2 and in particular to polypeptides capable of modulating signal transduction from CXCR2. The invention also relates to nucleic acids, vectors and host cells capable of expressing the polypeptides of the invention, pharmaceutical compositions comprising the polypeptides and uses of said polypeptides and compositions for treatment of diseases involving aberrant functioning of CXCR2.