公开(公告)号：US5585373A

公开(公告)日：1996-12-17

申请号：US341177

申请日：1994-11-18

申请人： Zhang Z. Ping ,  Zhen J. Sheng ,  Zhang Q. Rong ,  Zhang J. Liang ,  Singh Rajeshwar ,  Tomohiro Yamashita ,  Toshiyuki Toko ,  Hiroshi Matsumoto

发明人： Zhang Z. Ping ,  Zhen J. Sheng ,  Zhang Q. Rong ,  Zhang J. Liang ,  Singh Rajeshwar ,  Tomohiro Yamashita ,  Toshiyuki Toko ,  Hiroshi Matsumoto

IPC分类号： A61K31/42 ,  A61P35/00 ,  B01J23/40 ,  B01J27/232 ,  C07D503/00 ,  C07D503/18 ,  C07D498/047 ,  C07D205/08

CPC分类号： C07D503/00 ,  Y02P20/55

摘要： A derivative of 3-(7'-oxo-1'-aza-4'-oxabicyclo[3.2.0 ]hept-3'-yl)propionic acid represented by the formula ##STR1## wherein R.sub.1 is a hydrogen atom, a lower alkyl group optionally having one or more cycloalkyl groups, a lower acyl group, a benzoyl group optionally having one or more substituents or a benzyl group optionally having one or more substituents, R.sub.2 is a hydrogen atom or a carboxyl-protecting group, R.sub.3 is a hydroxyl group, an azido group, a benzenesulfonyloxy group optionally having one or more substituents, a lower alkylsulfonyloxy group optionally having one or more substituents, a tri-substituted silyloxy group or an amino group optionally having one or more substituents, provided that when R.sub.1 and R.sub.2 are hydrogen atoms, R.sub.3 is not an amino group, and a salt thereof.

摘要翻译： 由式（I）表示的3-（7'-氧代-1'-氮杂-4'-氧杂双环[3.2.0]庚-3'-基）丙酸的衍生物，其中R1是氢原子 ，任选具有一个或多个环烷基的低级烷基，低级酰基，任选具有一个或多个取代基的苯甲酰基或任选具有一个或多个取代基的苄基，R 2是氢原子或羧基保护基， R3是羟基，叠氮基，任选具有一个或多个取代基的苯磺酰氧基，任选具有一个或多个取代基的低级烷基磺酰氧基，三取代的甲硅烷氧基或任选具有一个或多个取代基的氨基，条件是 当R 1和R 2是氢原子时，R 3不是氨基，及其盐。