公开(公告)号：US20120040380A1

公开(公告)日：2012-02-16

申请号：US13166627

申请日：2011-06-22

Applicant: SCHUYLER BOON CORRY ,  WILLIAM LOUIS DOWNEY ,  BRIAN FILANOSKI ,  KYLE RICHARD GEE ,  I. LAWRENCE GREENFIELD ,  JAMES DAVID HIRSCH ,  IAIN JOHNSON ,  ALEKSEY RUKAVISHNIKOV

Inventor： SCHUYLER BOON CORRY ,  WILLIAM LOUIS DOWNEY ,  BRIAN FILANOSKI ,  KYLE RICHARD GEE ,  I. LAWRENCE GREENFIELD ,  JAMES DAVID HIRSCH ,  IAIN JOHNSON ,  ALEKSEY RUKAVISHNIKOV

IPC: G01N21/64 ,  C09B29/36 ,  C12Q1/34

CPC classification number: C07F5/022 ,  C07D499/00 ,  C07D501/00 ,  C07D501/58 ,  C07D501/60 ,  C07D503/00 ,  C07D519/00 ,  C12Q1/34 ,  C12Q2334/00 ,  G01N33/581 ,  G01N2333/986

Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.

Abstract translation: 本发明涉及作为酶的底物的化合物，并且在与酶反应时提供可检测的反应，例如可光学检测的反应。 特别地，这些化合物可用于检测样品中β-内酰胺酶的存在。 除了化合物之外，公开了用于分析样品存在β-乳糖酶的方法，例如，作为包括编码β-乳糖酶的序列的核酸序列的表达的指示剂。 公开了包括所公开的化合物和另外的组分的试剂盒，例如细胞，抗体，β-乳酸酶或在测定中使用组分的说明书。

公开(公告)号：US20090047692A1

公开(公告)日：2009-02-19

申请号：US12099085

申请日：2008-04-07

Applicant: Schuyler Boon CORRY ,  William Louis Downey ,  Brian Filanoski ,  Kyle Richard Gee ,  I. Lawrence Greenfield ,  James David Hirsch ,  Iain Johnson ,  Aleksey Rukavishnikov

Inventor： Schuyler Boon CORRY ,  William Louis Downey ,  Brian Filanoski ,  Kyle Richard Gee ,  I. Lawrence Greenfield ,  James David Hirsch ,  Iain Johnson ,  Aleksey Rukavishnikov

IPC: G01N33/53 ,  C07D501/60 ,  C07D498/04 ,  C12Q1/34

CPC classification number: C07F5/022 ,  C07D499/00 ,  C07D501/00 ,  C07D501/58 ,  C07D501/60 ,  C07D503/00 ,  C07D519/00 ,  C12Q1/34 ,  C12Q2334/00 ,  G01N33/581 ,  G01N2333/986

Abstract: The present invention relates to compounds that are substrates for an enzyme, and upon reaction with the enzyme provide a detectable response, such as an optically detectable response. In particular, the compounds have utility in detecting the presence of a β-lactamase in a sample. In addition to the compounds, methods are disclosed for analyzing a sample for the presence of a β-lactmase, for example, as an indicator of expression of a nucleic acid sequence including a sequence coding for a β-lactmase. Kits are disclosed that include the disclosed compounds and additional components, for example, cells, antibodies, a β-lactmase or instructions for using the components in an assay.

Abstract translation: 本发明涉及作为酶的底物的化合物，并且在与酶反应时提供可检测的反应，例如可光学检测的反应。 特别地，这些化合物可用于检测样品中β-内酰胺酶的存在。 除了化合物之外，公开了用于分析样品中存在β-内酰胺酶的方法，例如作为包括编码β-内酰胺酶的序列的核酸序列的表达的指示剂。 公开了包括公开的化合物和另外的组分的试剂盒，例如细胞，抗体，β-内酰胺酶或在测定中使用组分的说明书。

公开(公告)号：US20060079496A1

公开(公告)日：2006-04-13

申请号：US11290185

申请日：2005-11-30

Applicant: Johannes Booij ,  Geertruida Lefferts

Inventor： Johannes Booij ,  Geertruida Lefferts

IPC: A61K31/43 ,  A61K31/407 ,  C07D487/08

CPC classification number: C07D503/00 ,  A61K9/1688 ,  A61K31/424 ,  A61K31/43 ,  C07D499/00 ,  Y10T428/2982 ,  A61K31/42 ,  A61K2300/00

Abstract: The present invention describes novel agglomerates in crystalline form of β-lactum compounds, Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactum compound in a solvent is mixed with one or more anti-solvents has been described.

Abstract translation: 本发明描述了β-内酯化合物的结晶形式的新型附聚物。此外，制备所述附聚物的方法，其中将至少一种β-内酯化合物在溶剂中的溶液或悬浮液与一种或多种抗坏血酸混合， 已经描述了溶剂。

公开(公告)号：US06979735B1

公开(公告)日：2005-12-27

申请号：US09937834

申请日：2000-04-03

Applicant: Johannes Booij ,  Ageeth Geertruida Lefferts

Inventor： Johannes Booij ,  Ageeth Geertruida Lefferts

IPC: A61K9/16 ,  A61K31/424 ,  A61K31/43 ,  C07D499/00 ,  C07D503/00 ,  C07D503/18

CPC classification number: C07D503/00 ,  A61K9/1688 ,  A61K31/424 ,  A61K31/43 ,  C07D499/00 ,  Y10T428/2982 ,  A61K31/42 ,  A61K2300/00

Abstract: The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more anti-solvents has been described.

Abstract translation: 本发明描述了β-内酰胺化合物的结晶形式的新型附聚物。 此外，已经描述了制备所述附聚物的方法，其中将至少一种β-内酰胺化合物在溶剂中的溶液或悬浮液与一种或多种抗溶剂混合。

公开(公告)号：US20040063930A1

公开(公告)日：2004-04-01

申请号：US10380686

申请日：2003-10-10

Inventor： Klaus Mosbach ,  Lei Ye ,  Yihua Yu

IPC: C07D487/04

CPC classification number: B01J20/26 ,  B01J20/268 ,  C07D503/00 ,  C12P17/188

Abstract: A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selective adsorption materials, are also disclosed.

Abstract translation: 使用选择性吸附材料，特别是分子印迹聚合物从克拉维酸中去除杂质的新方法。 还公开了适用于该方法的新型选择性吸附材料，以及制备这种选择性吸附材料的方法。

公开(公告)号：US06692950B1

公开(公告)日：2004-02-17

申请号：US08586664

申请日：1996-04-03

Applicant: Stephen William Elson ,  Neville Hubert Nicholson ,  Stefan Roland Woroniecki ,  Janice Arnell

Inventor： Stephen William Elson ,  Neville Hubert Nicholson ,  Stefan Roland Woroniecki ,  Janice Arnell

IPC: C12N121

CPC classification number: C12N9/0006 ,  C07D503/00 ,  C12P17/188

Abstract: A compound of formula (I), wherein R=H or Na, or a salt thereof and an enzyme, obtainable from Streptomyces species, having clavulanic acid dehydrogenase activity which is capable of converting (I) into clavulanic acid.

Abstract translation: 式（I）化合物，其中R = H或Na，或其盐和可从链霉菌属物种获得的具有能够将（I）转化为克拉维酸的克拉维酸脱氢酶活性的酶。

公开(公告)号：US20030219867A1

公开(公告)日：2003-11-27

申请号：US10367221

申请日：2003-02-14

Applicant: SmithKline Beecham plc

Inventor： Janice Arnell ,  Stephen William Elson ,  Neville Hubert Nicholson ,  Stefan Roland Woroniecki

IPC: C12P017/16 ,  C12N009/06 ,  C07H021/04 ,  C12N001/21 ,  C12P021/02 ,  C12N015/74

CPC classification number: C12N9/0006 ,  C07D503/00 ,  C12P17/188

Abstract: An isolated DNA fragment encoding a protein with CAD activity wherein the protein is clavulanic acid dehydrogenase (CAD) from S. clavuligerus, with the proviso that the isolated DNA fragment is not: (a) the 13.1 kb BglII to SphI fragment of S. clavuligerus; (b) the 10.8 kb EcoRI to BamHI fragment of S. clavuligerus; (c) the 8.8 kb BclI to BclII fragment of S. clavuligerus; (d) the 2.5 kb BglII to BglII fragment of S. clavuligerus; (e) the 60 kb BglII to BamHI fragment of S. clavuligerus; or (f) the 18.0 BclI to SphI fragment of S. clavuligerus.

Abstract translation: 编码具有CAD活性的蛋白质的分离的DNA片段，其中所述蛋白质是来自S.clavuligerus的克拉维酸脱氢酶（CAD），条件是分离的DNA片段不是：（a）S.clavuligerus的13.1kb BglII至SphI片段 ; （b）S.clavuligerus的10.8kb EcoRI到BamHI片段; （c）S.clavuligerus的8.8kb BclI至BclII片段; （d）S.clavuligerus的2.5kb BglII至BglII片段; （e）S.clavuligerus的60kb BglII至BamHI片段; 或（f）S.clavuligerus的18.0BclI至SphI片段。

公开(公告)号：US20030203886A1

公开(公告)日：2003-10-30

申请号：US10437097

申请日：2003-05-13

Inventor： Franz Krenmueller ,  Harald Summer

IPC: C07D487/08

CPC classification number: C07D503/00

Abstract: Use of the 2-amino-2,4,4-trimethylpentane salt of clavulanic acid as an intermediate in the production of pharmaceutically acceptable salts of clavulanic acid.

公开(公告)号：US4560552C1

公开(公告)日：2001-10-16

申请号：US33045681

申请日：1981-12-14

Applicant: BEECHAM GROUP LTD

Inventor： COLE MARTIN ,  HOWARTH THOMAS T ,  READING CHRISTOPHER

IPC: A61K31/42 ,  A61K31/43 ,  A61P31/04 ,  C07D503/00 ,  C12N9/99 ,  C12P1/06 ,  C12P17/18 ,  C12P37/04 ,  A61K35/00

CPC classification number: C12P17/188 ,  A61K31/42 ,  A61K31/43 ,  C07D503/00 ,  A61K2300/00

Abstract: A new antibacterially active agent has been isolated from Streptomyces clavuligerus. This new compound which is designated clavulanic acid has the formula (I): (I) In addition to being a broad spectrum antibiotic of medium potency, clavulanic acid and its salts and esters have the ability to enhance the effectiveness of beta -lactam antibiotics against many beta -lactamase producing bacteria.

公开(公告)号：US20010007761A1

公开(公告)日：2001-07-12

申请号：US09754231

申请日：2001-01-03

Inventor： Egidij Capuder

IPC: C12P017/18 ,  C07D487/04

CPC classification number: C12P17/188 ,  C07D503/00 ,  C12N1/02 ,  Y10S435/886

Abstract: A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth without prior treatment.

Abstract translation: 从产生克拉维酸的微生物的水性发酵液中分离克拉维酸及其药学上可接受的盐（例如克拉维酸钾）的方法包括没有预处理的肉汤的微量过滤。