公开(公告)号：US09797904B2

公开(公告)日：2017-10-24

申请号：US14428334

申请日：2012-09-13

申请人： Jie He ,  Fengwei Tan ,  Zhaoli Chen ,  Nan Sun

发明人： Jie He ,  Fengwei Tan ,  Zhaoli Chen ,  Nan Sun

IPC分类号： C12N15/113 ,  G01N33/574 ,  C07K16/40 ,  C12Q1/68

CPC分类号： G01N33/57423 ,  C07K16/40 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/904

摘要： The present invention relates to a method for diagnosing the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a diagnostic biomarker. The present invention also relates to a method for predicting the prognosis of the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a prognostic biomarker. The present invention further relates to a method to suppress proliferation of lung tumor cells in a subject, decrease growth of lung tumor cells in a subject, or improve survival of a subject with lung cancer by using isocitrate dehydrogenase 1 as a therapeutic target.