公开(公告)号：US20190049468A9

公开(公告)日：2019-02-14

申请号：US15261674

申请日：2016-09-09

申请人： TERUMO KABUSHIKI KAISHA

发明人： Shouji Ochiai ,  Takeyuki Moriuchi ,  Masao Takinami

IPC分类号： G01N33/72 ,  C12Q1/54 ,  G01N21/35 ,  G01N21/31

CPC分类号： G01N33/721 ,  C12Q1/54 ,  C12Y101/03004 ,  C12Y111/01 ,  G01N21/27 ,  G01N21/274 ,  G01N21/31 ,  G01N21/35 ,  G01N21/78 ,  G01N21/783 ,  G01N21/8483 ,  G01N33/66 ,  G01N2201/061 ,  G01N2201/12 ,  G01N2333/805 ,  G01N2333/904 ,  G01N2333/908

摘要： Provided is a component measuring apparatus configured to determine a functional form that describes wavelength characteristics of a variation attributable to scattering (S (λ)). The apparatus then determines unknown one or more coefficients (p, q) based on a first relational expression that involves a variation attributable to absorption (H (λ1)) and a group of second relational expressions that do not involve variations attributable to absorption (H (λ2a), H (λ2b), H (λ2c)). The apparatus then corrects an absorbance measured at an arbitrary wavelength (λ) using a function where the one or more coefficients (p, q) are applied to the functional form so as to reduce or eliminate at least the effects of scattering of light.

公开(公告)号：US20180344818A1

公开(公告)日：2018-12-06

申请号：US15269943

申请日：2016-09-19

申请人： PRO NATURA GESELLSCHAFT FUR GESUNDE ERNAHRUNG MBH

发明人： Daniel Henry WYROBNIK ,  Isaac Harry WYROBNIK ,  Elliad Ronen SILCOFF

IPC分类号： A61K38/47 ,  A23L29/00 ,  A23L5/20 ,  A61K9/48 ,  A61K38/52 ,  C12Q1/32 ,  A61K38/44

CPC分类号： A61K38/47 ,  A23L5/20 ,  A23L29/06 ,  A23V2002/00 ,  A61K9/48 ,  A61K38/443 ,  A61K38/52 ,  C12Q1/32 ,  C12Y101/01124 ,  C12Y302/0102 ,  C12Y302/01026 ,  C12Y503/01005 ,  G01N2333/904 ,  G01N2800/04 ,  G01N2800/38 ,  A23V2200/328 ,  A61K2300/00

摘要： 5-D-fructose dehydrogenase, optionally in combination with invertase and/or maltase and/or glucose isomerase, may be used to treat fructose intolerance. Other embodiments are also disclosed.

公开(公告)号：US09957543B2

公开(公告)日：2018-05-01

申请号：US15079002

申请日：2016-03-23

申请人： Ikeda Food Research Co., Ltd.

发明人： Hironori Omura ,  Hirokazu Sanada ,  Takako Yada ,  Ayaka Atsumi ,  Tetsunari Morita ,  Emi Ishimaru

IPC分类号： C12Q1/32 ,  C07H21/04 ,  C12Q1/00 ,  C12N9/02 ,  C12N9/04 ,  G01N27/327

CPC分类号： C12Q1/006 ,  C12N9/0004 ,  C12N9/0006 ,  C12Q1/004 ,  C12Q1/32 ,  C12Y101/05 ,  C12Y101/9901 ,  G01N27/3271 ,  G01N2333/904

摘要： The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low action on maltose. The present invention relates to a polynucleotide encoding a soluble coenzyme-linked glucose dehydrogenase that catalyzes the oxidation of glucose in the presence of an electron acceptor and has an activity toward maltose of 5% or lower; a polypeptide encoded by the nucleotide sequence of the polynucleotide; a recombinant vector carrying the polynucleotide; a transformed cell produced using the recombinant vector; a method for producing a polypeptide comprising culturing the transformed cell and collecting from the cultivated products a polypeptide that links to FAD to exert the glucose dehydration activity; a method for determination of glucose using the polypeptide; a reagent composition for determination of glucose; and a biosensor.

公开(公告)号：US09797904B2

公开(公告)日：2017-10-24

申请号：US14428334

申请日：2012-09-13

申请人： Jie He ,  Fengwei Tan ,  Zhaoli Chen ,  Nan Sun

发明人： Jie He ,  Fengwei Tan ,  Zhaoli Chen ,  Nan Sun

IPC分类号： C12N15/113 ,  G01N33/574 ,  C07K16/40 ,  C12Q1/68

CPC分类号： G01N33/57423 ,  C07K16/40 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/904

摘要： The present invention relates to a method for diagnosing the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a diagnostic biomarker. The present invention also relates to a method for predicting the prognosis of the lung cancers such as non small lung cancer in a subject by using isocitrate dehydrogenase 1 as a prognostic biomarker. The present invention further relates to a method to suppress proliferation of lung tumor cells in a subject, decrease growth of lung tumor cells in a subject, or improve survival of a subject with lung cancer by using isocitrate dehydrogenase 1 as a therapeutic target.

公开(公告)号：US09755390B2

公开(公告)日：2017-09-05

申请号：US14394873

申请日：2013-04-17

申请人： NOVIOSENSE B.V.

发明人： Johannes Hendrikus Leonardus Hanssen ,  Christopher Wilson

IPC分类号： H01R43/033 ,  A61B5/1486 ,  G01N33/543 ,  A61N1/05 ,  H01R43/28 ,  H01M4/1399 ,  H01M4/137 ,  A61B5/145 ,  G01N33/487 ,  A61B5/00

CPC分类号： H01R43/033 ,  A61B5/0031 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2562/0215 ,  A61B2562/12 ,  A61N1/0563 ,  C12Q1/006 ,  G01N33/487 ,  G01N33/543 ,  G01N33/54306 ,  G01N33/5438 ,  G01N33/54393 ,  G01N2333/904 ,  H01M4/137 ,  H01M4/1399 ,  H01R43/28 ,  Y10T29/49018 ,  Y10T29/49194

摘要： A process for making a biosensor comprising a hollow coil having wires coiled in parallel and an electronic circuit component connected to the coil, the process including: 1) providing a mandrel on which wires including at least a first wire, a second wire and a third wire are wound in parallel, 2a) immersing the mandrel in a first buffer solution comprising a first bioreceptor, a first monomer and optional additives, 2b) arranging the wires such that the first wire may be used as a working electrode, the second wire may be used as a counter electrode and the third wire may be used as a reference electrode of a three electrode electrochemical cell used in an electropolymerization process, 3) passing electric current through the first wire to form a first biocompatible coating of a first polymer polymerized from the first monomer comprising the first bioreceptor on the first wire, 4) removing the coil from the mandrel, 5) connecting the wires to their respective points of the electronic circuit component such that the first wire may be used as a working electrode, the second wire may be used as a counter electrode and the third wire may be used as a reference electrode and wherein the electronic circuit component is configured such that it can generate an input signal for a wireless receiver based upon the activity of the bioreceptor and wirelessly send the input signal to the wireless receiver.

公开(公告)号：US09738780B2

公开(公告)日：2017-08-22

申请号：US15211278

申请日：2016-07-15

申请人： University of Washington through its Center for Commercialization

发明人： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC分类号： C08L33/14 ,  A61K41/00 ,  A61L27/34 ,  A61L27/52 ,  A61L31/10 ,  C07C229/12 ,  A61L29/08 ,  A61L29/14 ,  A61L31/14 ,  C08F26/02 ,  C08L33/10 ,  C08J3/075 ,  C12Q1/54

CPC分类号： C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

摘要： Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

公开(公告)号：US20170175168A1

公开(公告)日：2017-06-22

申请号：US15364762

申请日：2016-11-30

申请人： Theranos, Inc.

发明人： Douglas Matje ,  Ian Gibbons ,  Paul Patel ,  Elizabeth A. Holmes

IPC分类号： C12Q1/60 ,  C12Q1/44 ,  C12Q1/26

CPC分类号： C12Q1/60 ,  C12Q1/26 ,  C12Q1/44 ,  C12Q1/61 ,  C12Q2326/00 ,  C12Q2326/90 ,  C12Q2326/96 ,  C12Q2523/115 ,  G01N33/92 ,  G01N2333/904 ,  G01N2333/908 ,  G01N2333/92

摘要： Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates. The detectable product is measured at different times after assay initiation. A lipase, cholesterol esterase, cholesterol oxidase and a peroxidase may be used together to produce colored product in amounts directly proportional to the quantity of cholesterol converted. Methods for calculating very-low density lipoprotein cholesterol levels by further including triglyceride measurements are disclosed. Assays may be performed in a single reaction mixture, allowing more accurate and precise cholesterol determinations, including ratios of cholesterol sub-fractions to total cholesterol, at less expense, than would be expected by performing several different assays in different reaction mixtures.

公开(公告)号：US09670525B2

公开(公告)日：2017-06-06

申请号：US14420925

申请日：2013-08-30

申请人： KYOWA MEDEX CO., LTD.

发明人： Rie Utsugi ,  Yuki Katayama

IPC分类号： C12Q1/60

CPC分类号： C12Q1/60 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/44 ,  G01N33/92 ,  G01N2333/902 ,  G01N2333/904 ,  G01N2333/914 ,  G01N2333/918

摘要： Provided is a method for measuring cholesterol in high-density lipoprotein (HDL) simply and accurately. A method for measuring cholesterol in high-density lipoprotein in a specimen, comprising reacting the specimen with i) a cholesterol ester hydrolase and a cholesterol oxidase, or ii) a cholesterol ester hydrolase, an oxidized coenzyme, and a cholesterol dehydrogenase, in an aqueous medium comprising at least one substance selected from the group consisting of pyridinium salts and quaternary ammonium salts each having a specific structure, and a polyanion to form hydrogen peroxide or reduced coenzyme and measuring the formed hydrogen peroxide or reduced coenzyme.

公开(公告)号：US09650566B2

公开(公告)日：2017-05-16

申请号：US15208027

申请日：2016-07-12

申请人： Profusa, Inc.

发明人： Soya Gamsey ,  Natalie Wisniewski ,  Kristen Helton ,  William McMillan

IPC分类号： A61K49/00 ,  C09K11/06 ,  C07F15/00 ,  G01N33/497 ,  C12Q1/54

CPC分类号： A61B5/14552 ,  A61B5/0059 ,  A61B5/14532 ,  A61B2503/40 ,  A61K49/0036 ,  A61K49/0054 ,  A61K49/0073 ,  C07F15/0066 ,  C09K11/06 ,  C09K2211/185 ,  C12Q1/54 ,  G01N33/497 ,  G01N2333/904

摘要： Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.

公开(公告)号：US20170121753A1

公开(公告)日：2017-05-04

申请号：US15304710

申请日：2015-04-17

申请人： Dojindo Laboratories

发明人： Masafumi Iwamoto ,  Tomoya Tanaka ,  Eiji Watanabe ,  Masanobu Shiga

IPC分类号： C12Q1/32

CPC分类号： C12Q1/32 ,  G01N2333/904

摘要： A method for measuring concentration of dehydrogenase and substrate thereof in the presence of living cells, wherein an electron mediator that is hard to be reduced by living cells, for example, a compound represented by Formula (I) shown below, an electron mediator represented by the Formula (I) shown below and a measurement reagent for dehydrogenase and substrate thereof comprising the electron mediator are disclosed. A−L−M   (I) [In the Formula (I), A represents a structural part containing at least one anionic group, M represents a structural part for mediating electron transfer and L represents a linker part for linking the A of the M.]