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1.发明授权Clavine-producing strain, a process for the preparation thereof as well as a microbiological process for producing clavine alkaloids 失效产生克拉维氏菌株，其制备方法以及用于生产角叉菜碱生物碱的微生物过程
公开(公告)号：US4618581A
公开(公告)日：1986-10-21
申请号：US637524
申请日：1984-08-03
申请人： Maria Trinn , Gabriella Kordik , Eva Udvardy-Nagy nee Cserey Pechaany , Zsuzsanna Vida , Rzsebet Zsoka nee Somkuti
发明人： Maria Trinn , Gabriella Kordik , Eva Udvardy-Nagy nee Cserey Pechaany , Zsuzsanna Vida , Rzsebet Zsoka nee Somkuti
CPC分类号： C12R1/645 , C12N1/38 , C12P17/183
摘要： The invention relates to a new microbiological process for the preparation of clavine alkaloids of the general formula (I), ##STR1## wherein R stands for hydroxymethyl or methyl group, by cultivation of a Claviceps fusiformis strain in liquid submerged culture medium containing sources of carbon, nitrogen, mineral salts and optionally other additives, under aerobic conditions, in which a Claviceps fusiformis variant strain deposited under No. 00211 is used as alkaloid-producing strain. The invention further relates to a biologically pure culture of the Claviceps fusiformis variant strain No. 00211 obtained in a process in which a Claviceps fusiformis strain No. 00164 is grown in a solid culture medium containing sources of carbon, nitrogen, mineral salts and agar as well as an additive promoting the formation of cytochrome P-450, followed by the selective isolation of the new strain No. 00211.
摘要翻译： 本发明涉及通过在液体浸没培养基中培养克拉维克氏梭菌菌株来制备通式（I），其中R代表羟甲基或甲基的通式（I）的角鲨生物碱的新微生物方法， 在需氧条件下，碳，氮，矿物盐和任选的其它添加剂的来源，其中将根据第00211号沉积的克拉维酵母梭形变体菌株用作生物碱生产菌株。 本发明还涉及在将克拉维克氏梭菌菌株No.1404生长在含有碳源，氮源，矿物盐和琼脂源的固体培养基中的方法中获得的克拉维克氏梭菌变种菌株00211的生物学纯培养物，其中， 以及促进细胞色素P-450的形成的添加剂，然后选择性分离新菌株00211。
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