公开(公告)号：US20210217489A1

公开(公告)日：2021-07-15

申请号：US17002641

申请日：2020-08-25

Applicant: 10X Genomics, Inc

Inventor： Michael Schnall-Levin ,  Lawrence Greenfield

IPC: G16B30/00 ,  C12Q1/6874 ,  C12N15/10 ,  C12Q1/6806

Abstract: Compositions, processes and systems are provided for preparing and analyzing sample indexing of nucleic acid libraries for multiplexed sequencing analysis of diverse sample sets.

公开(公告)号：US20170016041A1

公开(公告)日：2017-01-19

申请号：US15156628

申请日：2016-05-17

Applicant: 10X Genomics, Inc.

Inventor： Lawrence Greenfield ,  Christopher Hindson

IPC: C12P19/34

Abstract: The disclosure provides stabilized reducing agents and methods for using them in sample preparation. Stabilized reducing agents described herein provide easy-to-use replacement reducing agents for reducing agents that undergo side-reactions that can render them ineffective as reducing agents and/or decrease the concentration of available reducing agent. In some cases, a stabilized reducing agent is an activatable reducing agent that can be activated upon application of a stimulus to the reducing agent.

Abstract translation: 本公开提供了稳定的还原剂和在样品制备中使用它们的方法。 本文所述的稳定的还原剂提供易于使用的还原剂，其用于还原剂，所述还原剂经历可能使其作为还原剂无效的副反应和/或降低可用的还原剂的浓度。 在一些情况下，稳定的还原剂是可活化的还原剂，其可以在向还原剂施加刺激时被活化。

公开(公告)号：US20200270664A1

公开(公告)日：2020-08-27

申请号：US16809280

申请日：2020-03-04

Applicant: 10X Genomics, Inc.

Inventor： Lawrence Greenfield ,  Christopher Hindson

IPC: C12P19/34 ,  C07C323/41 ,  C12Q1/6806 ,  C12Q1/6848

Abstract: The disclosure provides stabilized reducing agents and methods for using them in sample preparation. Stabilized reducing agents described herein provide easy-to-use replacement reducing agents for reducing agents that undergo side-reactions that can render them ineffective as reducing agents and/or decrease the concentration of available reducing agent. In some cases, a stabilized reducing agent is an activatable reducing agent that can be activated upon application of a stimulus to the reducing agent.