公开(公告)号：US20210327544A1

公开(公告)日：2021-10-21

申请号：US17233029

申请日：2021-04-16

Applicant: 10x Genomics, Inc.

Inventor： David Jaffe ,  Sreenath Krishnan ,  Wyatt McDonnell ,  Michael Stubbington

IPC: G16B45/00 ,  G16B25/10 ,  G16B30/00

Abstract: An interactive visualization system is disclosed herein. The system includes a data source, user input device, processor, and display. The data source obtains a B cell receptor and/or T cell receptor data source. The user input device receives a user selected parameter under which to analyze the data set. The processor identifies a clonotype group in the data set using the parameter, identifies subclonotypes within the clonotype group (wherein each identified subclonotype comprises cells having identical V(D)J transcripts), and processes the data to define a visualization model that can display a compressed view of the identified clonotype group. The display renders a visualization of said data set according to said visualization model. The visualization displays the clonotype group by identified subclonotype.

公开(公告)号：US11131664B2

公开(公告)日：2021-09-28

申请号：US16375129

申请日：2019-04-04

Applicant: 10X Genomics, Inc.

Inventor： Katherine Pfeiffer ,  Sarah Taylor ,  Michael Stubbington

IPC: C40B50/06 ,  G01N33/532 ,  C07K14/74 ,  C12N15/85 ,  G01N33/543 ,  G01N33/548 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6806 ,  G01N33/50 ,  G01N33/53 ,  G01N33/58 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  C12N15/11 ,  G01N33/569 ,  C40B70/00 ,  C40B30/04

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including generation of labeled macromolecules, including major mistocompatability complex (MHC) molecules, dextramers, etc. Labeled macromolecules may be generated using an in vitro transcription reaction. Labeled macromolecules may be generated in one or more partitions.

公开(公告)号：US11002731B2

公开(公告)日：2021-05-11

申请号：US16375110

申请日：2019-04-04

Applicant: 10X Genomics, Inc.

Inventor： Katherine Pfeiffer ,  Sarah Taylor ,  Michael Stubbington

IPC: C40B30/04 ,  G01N33/532 ,  C07K14/74 ,  C12N15/85 ,  G01N33/543 ,  G01N33/548 ,  C12N15/10 ,  C12Q1/6804 ,  C12Q1/6806 ,  G01N33/50 ,  G01N33/53 ,  G01N33/58 ,  C12Q1/6818 ,  C12Q1/6827 ,  C12Q1/6881 ,  C12N15/11 ,  G01N33/569 ,  C40B70/00

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and antigen screening. Polynucleotide processing may be useful for a variety of applications. Antigen screening may comprise the use of one or more engineered cells. Engineered cells may be useful for characterizing one or more analytes including, for example, a polypeptide antigen.