公开(公告)号：US20230416750A1

公开(公告)日：2023-12-28

申请号：US18035871

申请日：2021-11-09

申请人： 1E Therapeutics Ltd.

发明人： Ido Bachelet ,  Almogit Horowitz ,  Alexander Rosenberg ,  Anastasia Shapiro ,  Ron Oshri ,  Ilana Kolodkin-Gal ,  Adva Levy-Zamir ,  Gat Krieger ,  Ella GILLIS ,  Shmulik ITTAH

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K47/54 ,  A61K31/7088 ,  A61P31/04

CPC分类号： C12N15/1137 ,  A61K45/06 ,  A61K47/554 ,  A61K31/7088 ,  A61P31/04 ,  C12Y305/02006

摘要： An oligonucleotide is provided. The oligonucleotide comprising a nucleic acid sequence of at least one DNAzyme, the DNAzyme being capable of silencing at least one target gene of a bacteria to thereby render the bacteria susceptible to antibiotic treatment.