公开(公告)号：US20030064508A1

公开(公告)日：2003-04-03

申请号：US10247745

申请日：2002-09-20

申请人： 3-DIMENSIONAL PHARMACEUTICALS, INC.

发明人： Joseph Kwasnoski ,  Ernel O. Simpson ,  Edmund Graf

IPC分类号： C12M001/34

CPC分类号： B01L3/50851 ,  B01L2300/04 ,  B01L2300/0829 ,  B01L2300/12 ,  B01L2300/1805

摘要： The present invention is a multi-well vessel such as a microtiter plate, made from a plastic material formulated for increased thermal conductivity. In a preferred embodiment, the plastic material is a thermally conductive formulation of a cyclic polyolefin, syndiotactic polystyrene, polycarbonate, or liquid crystal polymer, with a melting point greater than 130null C. and exhibiting very low intrinsic fluorescent properties. A conductive medium, such as conductive carbon black, is included in the formulation of the plastic material at about 5% or greater by weight to increase thermal conductivity. To further increase thermal conductivity, a thermally conductive ceramic filler, such as a Boron Nitride filler, may be added to the formulation. A polymeric surfactant may also be added to the formulation for increased performance. The invention may also include a flat piece of conductive material attached to the flat bottom of the plate to impart conductivity and flatness to the part. Alternatively, the flat bottom surface of the plate may be metallized or coated with a flat layer of conductive material. The plate may also include a transparent lid, or cover, preferably made from polycarbonates, polypropylenes, or cyclic olefins or from multi-layer films made from two or more clear materials with desired barrier properties. Additionally, a fluorescent grade of polymer, such an epoxy prepared with a fluorescent die, can be embedded at a particular position on the plate to help indicate when the lights on the test equipment are in operation.

摘要翻译： 本发明是一种多孔容器，例如由配制用于增加导热性的塑料制成的微量滴定板。 在优选的实施方案中，塑料材料是环状聚烯烃，间同立构聚苯乙烯，聚碳酸酯或液晶聚合物的导热配方，其熔点大于130℃，表现出非常低的固有荧光性能。 导电性介质，例如导电炭黑，以约5％或更高的重量包含在塑料材料的制剂中以增加导热性。 为了进一步提高导热性，可以向制剂中加入导热陶瓷填料，例如氮化硼填料。 还可以将聚合物表面活性剂加入制剂中以提高性能。 本发明还可以包括附接到板的平坦底部的平坦导电材料片，以赋予该部件的导电性和平坦度。 或者，板的平坦底表面可以金属化或涂覆有导电材料的平坦层。 板还可以包括透明盖或盖，优选由聚碳酸酯，聚丙烯或环烯烃制成，或者由具有所需阻隔性能的两种或更多种透明材料制成的多层膜制成。 此外，荧光级别的聚合物，例如用荧光管芯制备的环氧树脂可以嵌入板上的特定位置，以帮助指示测试设备上的灯是否在运行。