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公开(公告)号:US20190242890A1
公开(公告)日:2019-08-08
申请号:US16340853
申请日:2017-10-11
申请人: Jim MANOLIOS
发明人: Jim MANOLIOS
IPC分类号: G01N33/555 , C12M1/00 , C12M1/02 , C12M1/26
CPC分类号: G01N33/555 , B01L3/50851 , B01L7/00 , B01L2300/1861 , B01L2400/0409 , C12M1/34 , C12M1/38 , C12M33/10 , C12M41/14 , C12M41/18 , C12M41/24 , G01N21/0332 , G01N21/07 , G01N33/80 , G01N35/00029 , G01N2035/00415 , G01N2035/00495
摘要: A method for incubating reagents, suspensions and/or biological products to a predetermined temperature for biological testing; the method comprising the steps of: a) providing a selected biological product in a receptacle and which is required to be incubated to a temperature which simulates a natural thermal environment of the biological product; b) applying controlled heating to or near the biological product using at least one laser emitting from a laser source for a time sufficient to reach a target temperature or which simulates a target temperature of the natural thermal environment in which the biological product exists.
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2.
公开(公告)号:US20190210027A1
公开(公告)日:2019-07-11
申请号:US15739318
申请日:2016-06-29
CPC分类号: B01L7/52 , B01L3/50851 , C12Q1/686 , G01N1/10 , G01N35/1095 , G01N2035/00465 , G01N2035/1032 , G01N2035/1034
摘要: Systems and methods for continuous flow polymerase chain reaction (PCR) are provided. The system comprises an injector, a mixer, a coalescer, a droplet generator, a detector, a digital PCR system, and a controller. The injector takes in a sample, partitions the sample into sample aliquots with the help of an immiscible oil phase, dispenses waste, and sends the sample aliquot to the mixer. The mixer mixes the sample aliquot with a PCR master mix and diluting water, dispenses waste, and sends the sample mixture (separated by an immiscible oil) to the coalescer. The coalescer coalesces the sample mixture with primers dispensed from a cassette, dispenses waste, and sends the reaction mixture (separated by an immiscible oil) to the droplet generator. The droplet generator converts the sample mixture into an emulsion where aqueous droplets of the reaction mixture are maintained inside of an immiscible oil phase and dispenses droplets to the digital PCR system. The digital PCR system amplifies target DNAs in the droplets. The detector detects target DNAs in the droplets. The controller controls the system to run automatically and continuously.
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公开(公告)号:US20190193075A1
公开(公告)日:2019-06-27
申请号:US16097111
申请日:2017-03-31
发明人: Guenter R. FUHR , Heiko ZIMMERMANN
CPC分类号: B01L3/50851 , A01N1/0268 , B01L2200/143 , B01L2200/147 , B01L2300/021 , B01L2300/0645 , B01L2300/1894 , G01K3/04 , G01K11/06 , G01N1/42 , G01N21/0332
摘要: The invention relates to a sample container that is designed to accommodate a cryogenically preserved biological sample, and to a method for producing the sample container. The invention further relates to a method for monitoring the temperature of a cryogenically preserved biological sample. The sample container that is designed to accommodate a cryogenically preserved biological sample has, on a region of its outer surface, a frozen-solid indicator substance whose melting point is in a range from −20° C. to −140° C.
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公开(公告)号:US10073036B2
公开(公告)日:2018-09-11
申请号:US15341418
申请日:2016-11-02
发明人: Gal Ingber , William G. Atterbury , Dave Holley , Thomas A. Klausing , John S. Laudo , Jason A. Schaefer , Sherwood Talbert , John Tallarico
CPC分类号: G01N21/6486 , B01L3/5085 , B01L3/50851 , B01L2200/025 , B01L2200/028 , B01L2200/04 , B01L2300/0609 , B01L2300/0809 , B01L2300/0851 , B01L2300/12 , B01L2300/168 , B01L2300/1844 , C12M41/36 , G01N21/0303 , G01N21/0332 , G01N35/026 , G01N2021/0382 , G01N2021/6419 , G01N2021/6421 , G01N2021/6482 , G01N2035/00346 , G01N2035/0429 , G01N2035/0449 , G01N2201/0633
摘要: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optical cup or cuvette having a tapered surface; an optics system including an optical reader and a thermal controller; an optical analyzer; a cooling system; and an improved spectrometer. The system may utilize the disposable cartridge in the sample processor and the optical cup or cuvette in the optical analyzer.
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5.
公开(公告)号:US09987636B2
公开(公告)日:2018-06-05
申请号:US14691340
申请日:2015-04-20
CPC分类号: B01L7/525 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/502746 , B01L3/50851 , B01L7/5255 , B01L2300/0609 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0487
摘要: Embodiments of the invention comprise microfluidic devices, instrumentation interfacing with those devices, processes for fabricating that device, and methods of employing that device to perform PCR amplification. Embodiments of the invention are also compatible with quantitative Polymerase Chain Reaction (“qPCR”) processes. Microfluidic devices in accordance with the invention may contain a plurality of parallel processing channels. Fully independent reactions can take place in each of the plurality of parallel processing channels. The availability of independent processing channels allows a microfluidic device in accordance with the invention to be used in a number of ways. For example, separate samples could be processed in each of the independent processing channels. Alternatively, different loci on a single sample could be processed in multiple processing channels.
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公开(公告)号:US20180135107A1
公开(公告)日:2018-05-17
申请号:US15870290
申请日:2018-01-12
申请人: Takara Bio USA, Inc.
发明人: Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号: C12Q1/686 , H01L27/144 , B01L3/00 , G01N21/01 , H01L31/18 , H01L31/0203 , H01L31/0232 , H01L31/024 , H01L31/105 , C12Q1/6806
CPC分类号: C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
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公开(公告)号:US20180135106A1
公开(公告)日:2018-05-17
申请号:US15870247
申请日:2018-01-12
申请人: Takara Bio USA, Inc.
发明人: Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号: C12Q1/686 , H01L27/144 , B01L3/00 , G01N21/01 , H01L31/18 , H01L31/0203 , H01L31/0232 , H01L31/024 , H01L31/105 , C12Q1/6806
CPC分类号: C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要: The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
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公开(公告)号:US20180111118A1
公开(公告)日:2018-04-26
申请号:US15636522
申请日:2017-06-28
发明人: Kieran Curran , David McGuire , Brian Chawke , Paul Fleming , Brian Barrett , Noel Sirr
IPC分类号: B01L3/00 , B01L3/02 , B01L7/00 , C12Q1/6806
CPC分类号: B01L3/502 , B01L3/022 , B01L3/50851 , B01L7/00 , B01L7/52 , B01L2200/0605 , B01L2200/0673 , B01L2200/0684 , B01L2300/0829 , B01L2300/0838 , B01L2300/12 , B01L2300/161 , B01L2300/1827 , B01L2300/1883 , B01L2300/1894 , B01L2400/0406 , B01L2400/0487 , C12Q1/6806
摘要: Devices, systems and methods for making and handling liquid samples are disclosed.
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公开(公告)号:US09865985B1
公开(公告)日:2018-01-09
申请号:US13923344
申请日:2013-06-20
申请人: Teradiode, Inc.
发明人: Bien Chann , Robin Huang , Parviz Tayebati
IPC分类号: H01S3/10 , H01S3/105 , B01L3/00 , G01N1/31 , G01N1/38 , H01S5/0625 , H01S5/40 , H01S5/022 , H01S3/101 , H01S5/00 , H01S3/00 , H01S5/14 , H01S3/1055 , H01S3/063 , H01S3/081 , H01S3/08
CPC分类号: H01S3/105 , B01L3/50851 , B01L2200/147 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , G01N1/31 , G01N1/38 , H01S3/0085 , H01S3/0635 , H01S3/08009 , H01S3/0812 , H01S3/10 , H01S3/10023 , H01S3/101 , H01S3/1055 , H01S5/0071 , H01S5/0085 , H01S5/02288 , H01S5/02292 , H01S5/06253 , H01S5/143 , H01S5/4012 , H01S2301/20
摘要: A system and method for tuning and infrared source laser in the Mid-IR wavelength range. The system and method comprising, at least, a plurality of individually tunable emitters, each emitter emitting a beam having a unique wavelength, a grating, a mirror positioned after the grating to receive at least one refracted order of light of at least one beam and to redirect the beam back towards the grating, and a micro-electro-mechanical systems device containing a plurality of adjustable micro-mirrors.
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公开(公告)号:US09827566B2
公开(公告)日:2017-11-28
申请号:US15157428
申请日:2016-05-18
发明人: Shlomo Turgeman , Ben Zion Lavi , Eitan Sheffer
CPC分类号: B01L3/5085 , B01L3/50851 , B01L3/50855 , B01L2200/025 , B01L2200/147 , B01L2300/0645 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1811 , B01L2300/1822 , B01L2300/1827 , G01F22/00 , G01G17/04
摘要: There is provided plate equipped with a mechanism to facilitate determination of the amount of a fluid added to or removed from a well in the plate. Other embodiments are also described.
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