公开(公告)号：US20210317116A1

公开(公告)日：2021-10-14

申请号：US17250073

申请日：2019-05-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： George W. GRIESGRABER ,  Hannah C. COHEN ,  Jana NINKOVIC

IPC: C07D471/04 ,  A61P37/02 ,  A61K31/4745

Abstract: Imidazo[4,5-c]quinoline compounds of Formula (I) having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.

公开(公告)号：US20200181198A1

公开(公告)日：2020-06-11

申请号：US16339085

申请日：2017-09-28

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Minghua DAI ,  Amy K. McNULTY ,  Federica SGOLASTRA ,  Jie LIU ,  Jana NINKOVIC ,  Robert T. FITZSIMONS, JR.

IPC: C07K7/08

Abstract: A polypeptide having a sequence at least 70% identical to SEQ ID NO: 1 (YVSPGMKNVNWWSHWWHATD) is provided. The polypeptide includes no more than 100 total amino acid residues.