公开(公告)号：US20220062157A1

公开(公告)日：2022-03-03

申请号：US17419397

申请日：2019-12-26

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Amanda C. ENGLER ,  Katie F. WLASCHIN ,  Hannah C. COHEN ,  Yizhong Wang ,  Tiffany T. TON ,  Jie Yang ,  Joel D. Oxman ,  Emily M. Wollmuth

IPC: A61K8/92 ,  A61K8/02 ,  A61Q11/00

Abstract: Articles that include from 20 wt-% to 45 wt-% of one or more plant based oils based on the total weight of the article; from 50 wt-% to 70 wt-% of one or more polymer film formers based on the total weight of the article; and from 5 wt-% to 15 wt-% of one or more humectants based on the total weight of the article. Further articles comprises this combination of oil, film former and humectant as a first layer adjacent to which a second layer comprises a mucoadhesive polymer. The articles may be used to prevent formation or maintenance of biofilm in an oral tissue, affect hydration loss in an oral tissue, affect lubricity or lubriciousness in an oral tissue or treat xerostomia or dry mouth. Preferred polymer film formers include pullulan, xanthan gum, HP guar, ethyl cellulose and carrageenan.

公开(公告)号：US20210317116A1

公开(公告)日：2021-10-14

申请号：US17250073

申请日：2019-05-23

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： George W. GRIESGRABER ,  Hannah C. COHEN ,  Jana NINKOVIC

IPC: C07D471/04 ,  A61P37/02 ,  A61K31/4745

Abstract: Imidazo[4,5-c]quinoline compounds of Formula (I) having a substituent that is attached at the N−1 position by a branched group, single enantiomers of the compounds, pharmaceutical compositions containing the compounds, and methods of making the compounds are disclosed. Methods of use of the compounds as immune response modifiers, for inducing cytokine biosynthesis in humans and animals, and in the treatment of diseases including infectious and neoplastic diseases are also disclosed.