公开(公告)号：US20150072966A1

公开(公告)日：2015-03-12

申请号：US14381636

申请日：2013-02-28

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Joseph V. Boykin, JR. ,  Stephanie F. Bernatchez ,  Vinod P. Menon ,  Joseph J. Stoffel ,  Joseph A. Tucker

IPC: G01N33/84 ,  A61K31/198 ,  A61K31/573

CPC classification number: G01N33/84 ,  A61K31/198 ,  A61K31/573 ,  G01N33/523 ,  G01N2800/20 ,  Y10T436/173076

Abstract: A method of establishing a therapeutic window of wound fluid nitric oxide (WFNO) in the wound of a mammal, the method including: obtaining a wound fluid sample from a mammal; analyzing the WFNO level; determining whether the WFNO is at or below a lower threshold level, or is at or above an upper threshold level; wherein the lower threshold level and upper threshold level define the therapeutic window of WFNO; and treating the mammal with a substance that alters the WFNO level such that the therapeutic window of WFNO in the wound is established.

Abstract translation: 一种在哺乳动物的伤口中建立伤口液一氧化氮（WFNO）的治疗窗口的方法，所述方法包括：从哺乳动物获得伤口液样品; 分析WFNO水平; 确定WFNO是否处于或低于较低阈值水平，或处于或高于上阈值水平; 其中下阈值水平和上阈值水平定义了WFNO的治疗窗口; 并用改变WFNO水平的物质治疗哺乳动物，使得创伤中的WFNO的治疗窗口成立。