公开(公告)号：US20220107326A1

公开(公告)日：2022-04-07

申请号：US17553259

申请日：2021-12-16

申请人： A-Alpha Bio, Inc. ,  Olympic Protein Sciences LLC

发明人： David Younger ,  David Colby ,  Randolph Lopez ,  Michael Wittekind

IPC分类号： G01N33/68

摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

公开(公告)号：US11474111B2

公开(公告)日：2022-10-18

申请号：US17553259

申请日：2021-12-16

申请人： A-Alpha Bio, Inc. ,  Olympic Protein Sciences LLC

发明人： David Younger ,  David Colby ,  Randolph Lopez ,  Michael Wittekind

IPC分类号： G01N33/68 ,  C12N15/10 ,  C12N15/81

摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

公开(公告)号：US20220251543A1

公开(公告)日：2022-08-11

申请号：US17619506

申请日：2021-06-01

申请人： A-Alpha Bio, Inc. ,  Olympic Protein Sciences LLC

发明人： David Younger ,  David Colby ,  Randolph Lopez ,  Michael Wittekind

IPC分类号： C12N15/10 ,  C12N1/16 ,  C12N15/81

摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

公开(公告)号：US11726097B2

公开(公告)日：2023-08-15

申请号：US17901986

申请日：2022-09-02

申请人： A-Alpha Bio, Inc.

发明人： David Younger ,  David Colby ,  Randolph Lopez ,  Michael Wittekind

IPC分类号： G01N33/68 ,  C12N15/10 ,  C12N15/81 ,  C12N1/16

CPC分类号： G01N33/6845 ,  C12N1/16 ,  C12N15/102 ,  C12N15/1037 ,  C12N15/1055 ,  C12N15/81 ,  C12N2800/102

摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.

公开(公告)号：US20230003737A1

公开(公告)日：2023-01-05

申请号：US17901986

申请日：2022-09-02

申请人： A-Alpha Bio, Inc. ,  Olympic Protein Sciences LLC

发明人： David Younger ,  David Colby ,  Randolph Lopez ,  Michael Wittekind

IPC分类号： G01N33/68 ,  C12N15/10 ,  C12N15/81 ,  C12N1/16

摘要： Characterization of the binding dynamics at the interface between any two proteins that specifically interact plays a role in myriad biomedical applications. The methods disclosed herein provide for the high-throughput characterization of the specific interaction at the interface between two protein binding partners and the identification of functionally significant mutations of one or both protein binding partners. For example, the methods disclosed herein may be useful for epitope and paratope mapping of an antibody-antigen pair, which is useful for the discovery and development of novel therapies, vaccines, diagnostics, among other biomedical applications.