公开(公告)号：US20240335471A1

公开(公告)日：2024-10-10

申请号：US18294039

申请日：2022-08-01

申请人： A2 Biotherapeutics, Inc.

发明人： Agnes Hamburger ,  Jee Young Mock ,  Mark Daris

IPC分类号： A61K35/17 ,  A61K39/00 ,  C12N5/0781 ,  C12N5/0783 ,  C12N5/0786 ,  C12N15/86

CPC分类号： A61K35/17 ,  A61K39/4631 ,  A61K39/4632 ,  A61K39/464411 ,  C12N5/0635 ,  C12N5/0636 ,  C12N5/0645 ,  C12N5/0646 ,  C12N15/86 ,  A61K2239/13 ,  A61K2239/17 ,  A61K2239/21 ,  A61K2239/22 ,  C12N2740/15043 ,  C12N2750/14143

摘要： The disclosure relates to a dual vector system with a first vector comprising a sequence encoding an inhibitory receptor and a sequence encoding a first part of an activator receptor; and a second vector, comprising a sequence encoding a second part of the activator receptor.

公开(公告)号：US20220389075A1

公开(公告)日：2022-12-08

申请号：US17755750

申请日：2020-11-10

申请人： A2 Biotherapeutics, Inc.

发明人： Julyun OH ,  Chang Yi ,  Dora Toledo Warshaviak ,  Jee Young Mock ,  Mark Daris ,  Agnes Hamburger ,  James Johnston ,  Carl Alexander Kamb

IPC分类号： C07K14/725 ,  C07K14/705 ,  C12N9/12 ,  C12N5/0783 ,  C12N15/85 ,  A61K35/17 ,  C07K14/73

摘要： Provided are engineered T-cell receptors comprising fusion proteins comprising a transmembrane domain and an intracellular domain capable of providing a stimulatory signal or an inhibitory signal, and immune cells comprising same.

公开(公告)号：US20220339194A1

公开(公告)日：2022-10-27

申请号：US17809409

申请日：2022-06-28

申请人： A2 Biotherapeutics, Inc.

发明人： Yuta Ando ,  Agnes Hamburger ,  Jee Young Mock ,  Julyun OH ,  Han Xu ,  Carl Alexander Kamb

IPC分类号： A61K35/17 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30

摘要： The disclosure relates to immune cells comprising a dual receptor system responsive to loss of heterozygosity in a target cell, and methods of making and using same. The first receptor comprises activator receptor specific to a HER2 antigen, and the second receptor comprises an inhibitory receptor specific to an antigen lost in cancer but not wild type cells, that inhibits activation of the immune cells by the first receptor.

公开(公告)号：US20230330227A1

公开(公告)日：2023-10-19

申请号：US18020728

申请日：2021-08-12

申请人： A2 Biotherapeutics, Inc.

发明人： Jee Young Mock ,  Carl Alexander Kamb ,  Agnes Hamburger

IPC分类号： A61K39/00 ,  C12N5/0783 ,  C12N15/86 ,  C07K14/47 ,  C07K14/72 ,  A61K31/138 ,  C07K14/725

CPC分类号： A61K39/4611 ,  C12N5/0636 ,  C12N15/86 ,  C07K14/4747 ,  C07K14/721 ,  A61K31/138 ,  A61K39/4621 ,  A61K39/4637 ,  A61K39/46431 ,  A61K39/4631 ,  C07K14/7051 ,  C12N2740/15043 ,  C07K2319/00 ,  A61K2239/25

摘要： The disclosure relates to fusion proteins comprising a tBID polypeptide and a steroid hormone receptor domain, and methods of using same to induce apoptosis in cells.