公开(公告)号：US20180171070A1

公开(公告)日：2018-06-21

申请号：US15860965

申请日：2018-01-03

申请人： AAT Bioquest, Inc. ,  Affymetrix, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Travis Jennings ,  Castle Funatake

IPC分类号： C08G61/12 ,  C09K11/06 ,  G01N33/533

CPC分类号： C08G61/128 ,  C08G61/12 ,  C08G2261/12 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/3142 ,  C08G2261/3242 ,  C08G2261/344 ,  C08G2261/411 ,  C08G2261/522 ,  C08G2261/72 ,  C08G2261/77 ,  C08G2261/94 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/145 ,  G01N33/533

摘要： The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.

公开(公告)号：US10316136B2

公开(公告)日：2019-06-11

申请号：US15860965

申请日：2018-01-03

申请人： AAT Bioquest, Inc. ,  Affymetrix, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Travis Jennings ,  Castle Funatake

IPC分类号： C08G61/12 ,  C09K11/06 ,  G01N33/533

摘要： The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.

公开(公告)号：US09896538B2

公开(公告)日：2018-02-20

申请号：US15469952

申请日：2017-03-27

申请人： AAT Bioquest, Inc. ,  Affymetrix, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Travis Jennings ,  Castle Funatake

IPC分类号： G01N33/533 ,  C09K11/06 ,  C08G61/12

CPC分类号： C08G61/128 ,  C08G61/12 ,  C08G2261/12 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/3142 ,  C08G2261/3242 ,  C08G2261/344 ,  C08G2261/411 ,  C08G2261/522 ,  C08G2261/72 ,  C08G2261/77 ,  C08G2261/94 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/145 ,  G01N33/533

摘要： The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.

公开(公告)号：US20170275418A1

公开(公告)日：2017-09-28

申请号：US15469952

申请日：2017-03-27

申请人： AAT Bioquest, Inc. ,  Affymetrix, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Travis Jennings ,  Castle Funatake

IPC分类号： C08G61/12 ,  G01N33/533 ,  C09K11/06

CPC分类号： C08G61/128 ,  C08G61/12 ,  C08G2261/12 ,  C08G2261/1424 ,  C08G2261/143 ,  C08G2261/3142 ,  C08G2261/3242 ,  C08G2261/344 ,  C08G2261/411 ,  C08G2261/522 ,  C08G2261/72 ,  C08G2261/77 ,  C08G2261/94 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/145 ,  G01N33/533

摘要： The invention provides for polyfluoreno[4,5-cde]oxepine conjugates and their use in methods of analyte detection.

公开(公告)号：US20220089943A1

公开(公告)日：2022-03-24

申请号：US17542223

申请日：2021-12-03

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Jixiang Liu ,  Qin Zhao ,  Ruogu Peng

IPC分类号： C09K11/06 ,  G01N21/64 ,  G01N33/533 ,  C08G61/12

摘要： Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.

公开(公告)号：US09810700B1

公开(公告)日：2017-11-07

申请号：US15610184

申请日：2017-05-31

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Jinfang Liao ,  Feng Liu

IPC分类号： C07D311/90 ,  G01N33/84 ,  C07D493/10 ,  C07C229/22 ,  C07F5/02 ,  C07D307/94 ,  G01N33/58

CPC分类号： G01N33/84 ,  C07C229/22 ,  C07D307/94 ,  C07D311/90 ,  C07D493/10 ,  C07F5/022 ,  C09B11/24 ,  C09B11/28 ,  C09B15/00 ,  C09B23/04 ,  C09B69/008 ,  G01N33/582

摘要： The present disclosure provides fluorogenic compounds useful for preparing fluorescent calcium ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators in methods of detection, discrimination and quantification of metal ions. The subject fluorogenic compounds and fluorescent ion indicators can include a chelating group based on a 2-aminophenoxyethylene glycol 2-aminoethyl ether, N,N,N′,N′-tetraacetic acid (PEGTA) moiety or precursor thereof where the phenyl group of the PEGTA is substituted with or fused with a fluorophore moiety of interest. The subject methods find use in the detection of intracellular calcium ions. Also provided are kits for use in practicing the subject methods.

公开(公告)号：US20200263084A1

公开(公告)日：2020-08-20

申请号：US16592464

申请日：2019-10-03

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Jixiang Liu ,  Qin Zhao ,  Ruogu Peng

IPC分类号： C09K11/06 ,  G01N21/64 ,  G01N33/533 ,  C08G61/12

摘要： Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.

公开(公告)号：US11827824B2

公开(公告)日：2023-11-28

申请号：US17542223

申请日：2021-12-03

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Jixiang Liu ,  Qin Zhao ,  Ruogu Peng

IPC分类号： C09K11/06 ,  G01N21/64 ,  G01N33/533 ,  C08G61/12

CPC分类号： C09K11/06 ,  C08G61/124 ,  G01N21/6428 ,  G01N33/533 ,  C08G2261/3241 ,  C09K2211/1466 ,  G01N2021/6439

摘要： Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.

公开(公告)号：US11220628B2

公开(公告)日：2022-01-11

申请号：US16592464

申请日：2019-10-03

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Jixiang Liu ,  Qin Zhao ,  Ruogu Peng

IPC分类号： C09K11/06 ,  G01N21/64 ,  G01N33/533 ,  C08G61/12

摘要： Fluorescent water soluble conjugated polymers including polycyclic aromatic comonomers are provided. The conjugated polymers can be linked to an acceptor fluorescent dye. The conjugated polymers find use in conjugates with biological substrates having applications in a variety of applications including methods of analyte detection.

公开(公告)号：US09346778B2

公开(公告)日：2016-05-24

申请号：US14975466

申请日：2015-12-18

申请人： AAT Bioquest, Inc.

发明人： Zhenjun Diwu ,  Haitao Guo ,  Ruogu Peng ,  Qin Zhao ,  Jixiang Liu ,  Jinfang Liao

IPC分类号： C07C229/60 ,  C07C247/02 ,  C07D307/94 ,  G01N33/533

CPC分类号： C07D307/94 ,  C07C229/60 ,  C07C247/04 ,  C07C2603/24 ,  C07D219/06 ,  C07D311/90 ,  C07D493/10 ,  C09B5/00 ,  G01N33/5041 ,  G01N33/533 ,  G01N33/84

摘要： Fluorescent dyes useful for preparing fluorescent metal ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators for the detection, discrimination and quantification of metal cations are provided.

摘要翻译： 提供了用于制备荧光金属离子指示剂的荧光染料，荧光指示剂本身，以及使用荧光指示剂来检测，鉴别和量化金属阳离子。