公开(公告)号：US20240254088A1

公开(公告)日：2024-08-01

申请号：US18442393

申请日：2024-02-15

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC分类号： C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/58

CPC分类号： C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/582

摘要： Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US11970454B1

公开(公告)日：2024-04-30

申请号：US18386399

申请日：2023-11-02

申请人： KING FAISAL UNIVERSITY

发明人： Hany Mohamed Abd El-Lateef Ahmed ,  Mai Mostafa Khalaf Ali ,  Antar Ahmed Abdelhamid Ahmed

IPC分类号： C07D219/06 ,  A61P31/04

CPC分类号： C07D219/06 ,  A61P31/04 ,  C07B2200/13

摘要： An ethyl 2-[9-(2-hydroxyquinolin-3-yl)-1,8-dioxo-3,4,9,10-tetrahydroacridine-10-yl]-acetate compound, its synthesis, and its use as an antimicrobial agent.

公开(公告)号：US11932603B2

公开(公告)日：2024-03-19

申请号：US17658438

申请日：2022-04-07

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Anand Natrajan ,  David Sharpe ,  Qingping Jiang ,  David Wen

IPC分类号： C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/58

CPC分类号： C07D219/06 ,  C09K11/07 ,  F21K2/06 ,  G01N21/76 ,  G01N33/543 ,  G01N33/582

摘要： Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.

公开(公告)号：US11866412B1

公开(公告)日：2024-01-09

申请号：US18116920

申请日：2023-03-03

申请人： KING FAISAL UNIVERSITY

发明人： Christophe Tratrat ,  Michelyne Haroun

IPC分类号： C07D219/06 ,  C07D471/04

CPC分类号： C07D219/06 ,  C07D471/04

摘要： Novel acridin-9-one derivative compounds having broad spectrum antibacterial activity, a method of making said compounds, methods of using said compounds, and a pharmaceutical composition comprising said compound(s) are provided. The acridin-9-one compounds have antimicrobial activity against various susceptible and resistant gram-positive and gram-negative bacteria as well as drug resistant bacteria. They act as DNA gyrase and topoisomerase IV inhibitors and are satisfiable as a drug for infectious treatment.

公开(公告)号：US20170144974A1

公开(公告)日：2017-05-25

申请号：US15189924

申请日：2016-06-22

申请人： Oregon Health & Science University ,  Government of the United states of America dba The Department of Veterans Affairs

发明人： Michael K. Riscoe ,  Rolf W. Winter ,  Jane X. Kelly ,  David J. Hinrichs ,  Martin J. Smilkstein

IPC分类号： C07D219/14 ,  C07D219/06

CPC分类号： C07D219/14 ,  A61K31/4706 ,  A61K31/473 ,  C07D219/06 ,  C07D401/06 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/423 ,  Y02A50/491

摘要： A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.

公开(公告)号：US09650357B2

公开(公告)日：2017-05-16

申请号：US14392352

申请日：2014-06-23

申请人： TOYO GOSEI CO., LTD.

发明人： Satoshi Enomoto

IPC分类号： C07D335/16 ,  G03F7/00 ,  H01L21/027 ,  H01L21/308 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  C07C33/24 ,  C07C35/38 ,  C07C35/40 ,  C07C43/23 ,  C07C49/83 ,  C07D219/06 ,  C07D309/12 ,  C07D311/86 ,  G03F7/16 ,  G03F7/20 ,  G03F7/36

CPC分类号： C07D335/16 ,  C07C33/24 ,  C07C35/38 ,  C07C35/40 ,  C07C43/23 ,  C07C49/83 ,  C07C2603/18 ,  C07C2603/24 ,  C07D219/06 ,  C07D309/12 ,  C07D311/86 ,  G03F7/0045 ,  G03F7/0382 ,  G03F7/0392 ,  G03F7/16 ,  G03F7/2051 ,  G03F7/36 ,  H01L21/0271 ,  H01L21/3081

摘要： A reagent that enhances acid generation of a photoacid generator and composition containing such reagent is disclosed.

公开(公告)号：US09618844B2

公开(公告)日：2017-04-11

申请号：US14891293

申请日：2014-05-13

申请人： TOYO GOSEI CO., LTD.

发明人： Satoshi Enomoto

IPC分类号： B44C1/22 ,  C03C15/00 ,  C03C25/68 ,  C23F1/00 ,  G03F7/004 ,  G03F7/039 ,  G03F7/20 ,  C07C33/24 ,  C07C35/38 ,  C07C35/40 ,  C07C49/83 ,  C07D219/06 ,  C07D309/12 ,  C07D311/86 ,  C07D335/16 ,  G03F7/16 ,  G03F7/36

CPC分类号： G03F7/0045 ,  C07C33/24 ,  C07C35/38 ,  C07C35/40 ,  C07C49/83 ,  C07C2603/18 ,  C07D219/06 ,  C07D309/12 ,  C07D311/86 ,  C07D335/16 ,  G03F7/0392 ,  G03F7/0397 ,  G03F7/16 ,  G03F7/20 ,  G03F7/2004 ,  G03F7/2037 ,  G03F7/2039 ,  G03F7/36

摘要： Described is a reagent that enhances acid generation of a photoacid generator and a composition containing such reagent.

公开(公告)号：US20160083388A1

公开(公告)日：2016-03-24

申请号：US14825481

申请日：2015-08-13

申请人： TRT PHARMA INC.

发明人： Gerald BATIST ,  Jian Hui WU

IPC分类号： C07D473/40 ,  C07D473/24 ,  C07D473/16

CPC分类号： C07D473/40 ,  A61K31/00 ,  A61K31/353 ,  A61K31/4433 ,  A61K31/473 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52 ,  C07D219/06 ,  C07D311/22 ,  C07D311/32 ,  C07D473/16 ,  C07D473/24 ,  C07D487/04

摘要： There is provided modulators of Nrf2 protein which comprises a compound which binds at least one of the BTB domain, IVR domain and Kelch domain of Keap1 protein, activating or inhibiting Nrf2. There is also provided pharmaceutical compositions containing the modulators, as well as uses and method of use of the modulators for the treatment of conditions.

公开(公告)号：US09139592B2

公开(公告)日：2015-09-22

申请号：US13704449

申请日：2011-05-31

申请人： Gerald Batist ,  Jian Hui Wu

发明人： Gerald Batist ,  Jian Hui Wu

IPC分类号： C07D487/04 ,  A61K31/00 ,  A61K31/353 ,  A61K31/4433 ,  A61K31/473 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52 ,  C07D219/06 ,  C07D311/22 ,  C07D311/32 ,  C07D473/16 ,  C07D473/24 ,  C07D473/40

CPC分类号： C07D473/40 ,  A61K31/00 ,  A61K31/353 ,  A61K31/4433 ,  A61K31/473 ,  A61K31/5025 ,  A61K31/519 ,  A61K31/52 ,  C07D219/06 ,  C07D311/22 ,  C07D311/32 ,  C07D473/16 ,  C07D473/24 ,  C07D487/04

摘要： The present invention is directed to a pharmaceutical composition comprising the following compound or a pharmaceutically acceptable salt thereof. The compound is a modulator of Nrf2 protein and binds at least one of the BTB domain, IVR domain and Kelch domain of Keap1 protein, activating or inhibiting Nrf2.

摘要翻译： 本发明涉及包含以下化合物或其药学上可接受的盐的药物组合物。 该化合物是Nrf2蛋白的调节剂，并结合Keap1蛋白的BTB结构域，IVR结构域和Kelch结构域中的至少一个，激活或抑制Nrf2。

公开(公告)号：US08987296B2

公开(公告)日：2015-03-24

申请号：US14066565

申请日：2013-10-29

申请人： Oregon Health & Science University ,  The United States of America DBA The Department of Veterans Affairs

发明人： Michael K. Riscoe ,  Rolf W. Winter ,  Jane X. Kelly ,  David J. Hinrichs ,  Martin J. Smilkstein

IPC分类号： A61K31/44 ,  C07D219/04 ,  C07D219/06 ,  C07D401/06 ,  C07D219/14

CPC分类号： C07D219/14 ,  A61K31/4706 ,  A61K31/473 ,  C07D219/06 ,  C07D401/06 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/423 ,  Y02A50/491

摘要： A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.

摘要翻译： 已经发现一类具有化学敏感性和抗寄生虫活性的吖啶酮化合物。 本文描述了用于治疗寄生虫感染如疟疾和弓形虫病的药物组合物和方法，并使抗药性细胞（例如多药耐药性细胞）对其它治疗剂敏感。 药物组合物和方法也可用于治疗和/或预防精神病如精神分裂症。