公开(公告)号：US20200071302A1

公开(公告)日：2020-03-05

申请号：US16610970

申请日：2018-05-22

Applicant: Abbisko Therapeutics Co., Ltd.

Inventor： Baowei ZHAO ,  Mingming ZHANG ,  Hongping YU ,  Shuqun YANG ,  Zhui CHEN ,  Yaochang XU

IPC: C07D401/14 ,  C07D413/14 ,  A61P35/00

Abstract: An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.

公开(公告)号：US20240327402A1

公开(公告)日：2024-10-03

申请号：US18576252

申请日：2022-08-03

Applicant: ABBISKO THERAPEUTICS CO., LTD.

Inventor： Tao FENG ,  Baowei ZHAO ,  Mingming ZHANG ,  Shuqun YANG ,  Hongping YU ,  Zhui CHEN ,  Yaochang XU

IPC: C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D403/14 ,  C07D519/00

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61P35/00 ,  C07D403/04 ,  C07D403/14 ,  C07D519/00

Abstract: A pyrimidine or pyridine derivative having a structure represented by formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as an EGFR inhibitor, and a use thereof in the preparation of a drug for treating and/or preventing cancer, tumors, or metastatic diseases associated at least in part with EGFR exon 20 insertions, deletions, or other mutations, especially a use thereof in the preparation of a drug for treating and/or preventing hyperproliferative diseases and the induction of cell death disorders.

公开(公告)号：US20200165254A1

公开(公告)日：2020-05-28

申请号：US16611345

申请日：2018-05-22

Applicant: Abbisko Therapeutics Co., Ltd.

Inventor： Baowei ZHAO ,  Mingming ZHANG ,  Hongping YU ,  Zhui CHEN ,  Yaochang XU

IPC: C07D487/04 ,  C07D487/14 ,  A61P35/02

Abstract: An azaaryl derivative with the structure of formula (I), a preparation method therefor and a pharmaceutical use thereof are disclosed in this application. The series of compounds of the this application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary site tumor metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.

公开(公告)号：US20230234970A1

公开(公告)日：2023-07-27

申请号：US18010920

申请日：2021-04-30

Applicant: Abbisko Therapeutics Co., Ltd.

Inventor： Mingming ZHANG ,  Baowei ZHAO ,  Fei YANG ,  Yongxian ZHANG ,  Hongping YU ,  Zhui CHEN ,  Yaochang XU

IPC: C07D519/00 ,  C07D471/04

CPC classification number: C07D519/00 ,  C07D471/04

Abstract: An immunosuppressant having the structure of formula (I), and a preparation method therefor and the use thereof are provided. The series of compounds can be widely used in the preparation of drugs for preventing and/or treating cancers or tumors, immune-related diseases and disorders, communicable diseases, infectious diseases or metabolic diseases mediated by PD-1/PD-L1 signal pathways, which drugs are expected to be developed into a new generation of PD-1/PD-L1 inhibitors.

公开(公告)号：US20230014651A1

公开(公告)日：2023-01-19

申请号：US17777767

申请日：2021-01-05

Applicant: Abbisko Therapeutics Co., Ltd.

Inventor： Mingming ZHANG ,  Baowei ZHAO ,  Fei YANG ,  Haiyan YING ,  Yongxian ZHANG ,  Hongping YU ,  Zhui CHEN ,  Yaochang XU

IPC: C07D471/04 ,  C07D519/00

Abstract: A biphenyl fluorine double bond derivative having a structure as represented by formula (I), a preparation method therefor, and a pharmaceutical application thereof. The biphenyl fluorine double bond derivative having the structure as represented by formula (I) can be widely applied in the preparation of medicaments for preventing and/or treating cancers or tumors, immune-related diseases and disorders, communicable diseases, infectious diseases or metabolic diseases mediated by PD-1/PD-L1 signal pathways, and is expected to be developed into a new generation of PD-1/PD-L1 inhibitors.