公开(公告)号：US20170183353A1

公开(公告)日：2017-06-29

申请号：US15313012

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. CRAVATT ,  Armand B. COGNETTA ,  Jonathan J. HULCE ,  Micah J. NIPHAKIS ,  Todd K. JONES ,  Cheryl A. GRICE

IPC: C07D487/04 ,  C12Q1/34

CPC classification number: C07D487/04 ,  C12Q1/34

Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.