公开(公告)号：US10336709B2

公开(公告)日：2019-07-02

申请号：US15764231

申请日：2016-09-29

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Micah Niphakis ,  Todd K. Jones

IPC: C07D233/80 ,  C07D233/86

Abstract: Provided herein are lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitors, pharmaceutical compositions thereof, and methods of their use for the treatment of disease.

公开(公告)号：US10093635B2

公开(公告)日：2018-10-09

申请号：US15814322

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D295/195

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09828379B2

公开(公告)日：2017-11-28

申请号：US14902324

申请日：2014-07-01

Applicant: Abide Therapeutics, Inc.

Inventor： Todd K. Jones ,  Justin S. Cisar ,  Cheryl A. Grice ,  Dong-Hui Wang ,  Olivia D. Weber

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/407

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The invention provides pyrrolo-pyrrole carbamate and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., solid tumor cancer, obesity, Down's syndrome, Alzheimer's disease, or pain, in a patient. The octahydropyrrolo pyrrole carbamates could be derived from hexafluoroisopropanol, N,N-disuccinimide and such. The activity of carbamates in MAGL, FAAH, and ABHD6 assays are also described.

公开(公告)号：US20170327500A1

公开(公告)日：2017-11-16

申请号：US15593239

申请日：2017-05-11

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. CISAR ,  Cheryl A. GRICE ,  Todd K. JONES ,  Olivia D. WEBER ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D471/10 ,  C07D519/00

CPC classification number: C07D471/10 ,  C07D519/00

Abstract: Provided herein are spirocycle compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09771341B2

公开(公告)日：2017-09-26

申请号：US15072229

申请日：2016-03-16

Applicant: Abide Therapeutics, Inc.

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Olivia D. Weber ,  Dong-Hui Wang

IPC: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D295/26 ,  C07D211/38 ,  C07D211/58 ,  C07D207/14 ,  C07D211/14 ,  C07D498/08 ,  C07D211/62 ,  C07D403/04 ,  C07D401/04 ,  C07D417/04 ,  C07D487/04 ,  C07D471/10 ,  C07D265/30 ,  C07D207/16

CPC classification number: C07D295/205 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/14 ,  C07D211/38 ,  C07D211/58 ,  C07D211/62 ,  C07D265/30 ,  C07D295/26 ,  C07D401/04 ,  C07D403/04 ,  C07D417/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or ABHD6. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180339970A1

公开(公告)日：2018-11-29

申请号：US15986747

申请日：2018-05-22

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  John J. M. WIENER ,  Olivia D. WEBER ,  Katharine K. DUNCAN

IPC: C07D231/14 ,  C07D401/06 ,  C07D403/12 ,  C07D417/12 ,  C07D413/12 ,  C07D417/14 ,  C07D401/12 ,  C07D403/06 ,  C07D487/04 ,  C07D519/00 ,  C07D471/10 ,  C07D403/14 ,  C07D413/14 ,  C07D451/02 ,  C07D491/048

CPC classification number: C07D231/14 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US20180327410A1

公开(公告)日：2018-11-15

申请号：US15777199

申请日：2016-11-18

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Todd K. JONES ,  Katherine K. DUNCAN ,  Olivia D. WEBER ,  Justin S. CISAR ,  Jeffrey E. MERIT

IPC: C07D487/04 ,  C07D487/10 ,  C07D403/06 ,  C07D519/00 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14

CPC classification number: C07D487/04 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D417/14 ,  C07D487/10 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL and/or FAAH. Furthermore, the subject compounds and compositions are useful for the treatment of, for example, pain.

公开(公告)号：US09981972B2

公开(公告)日：2018-05-29

申请号：US15313012

申请日：2015-05-20

Applicant: ABIDE THERAPEUTICS, INC. ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Benjamin F. Cravatt ,  Armand B. Cognetta ,  Jonathan J. Hulce ,  Micah J. Niphakis ,  Todd K. Jones ,  Cheryl A. Grice

IPC: C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D471/04 ,  C12Q1/34

CPC classification number: C07D487/04 ,  C12Q1/34

Abstract: Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases. Furthermore, the subject compounds and compositions are useful for the treatment of one or more of cancer, pain, diabetes, obesity/metabolic syndrome, epilepsy, traumatic brain injury, and inflammation.

公开(公告)号：US20180134674A1

公开(公告)日：2018-05-17

申请号：US15814322

申请日：2017-11-15

Applicant: ABIDE THERAPEUTICS, INC.

Inventor： Cheryl A. GRICE ,  Daniel J. BUZARD ,  Michael B. SHAGHAFI

IPC: C07D295/195

CPC classification number: C07D295/195 ,  C07D295/205

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US09567302B2

公开(公告)日：2017-02-14

申请号：US14383076

申请日：2013-03-15

Applicant: Abide Therapeutics, Inc. ,  The Scripps Research Institute

Inventor： Justin S. Cisar ,  Cheryl A. Grice ,  Todd K. Jones ,  Dong-Hui Wang ,  Olivia Weber ,  Benjamin F. Cravatt ,  Micah J. Niphakis ,  Armand Cognetta ,  Jae Won Chang

IPC: C07D207/46 ,  C07D401/12 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  A61K31/496 ,  A61K31/454 ,  C07D403/12 ,  C07D401/14 ,  C07D491/08 ,  C07D233/80 ,  C07D403/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/107 ,  C07D498/08 ,  C07D209/48

CPC classification number: C07D207/46 ,  C07D209/48 ,  C07D233/80 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D498/08

Abstract: Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.

Abstract translation: 本文提供了可用于治疗例如疼痛，实体瘤和/或肥胖症的氨基甲酸酯化合物。