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    COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES
    2.
    发明申请
    COMPOUNDS USEFUL FOR TREATING DISEASES CAUSED BY RETROVIRUSES 有权
    用于治疗由逆转录病毒引起的疾病的化合物

    公开(公告)号：US20160151348A1

    公开(公告)日：2016-06-02

    申请号：US14902935

    申请日：2014-07-04

    申请人： ABIVAX ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT CURIE ,  UNIVERSITE DE MONTPELLIER

    发明人： Jamal TAZI ,  Florence MAHUTEAU-BETZER ,  Romain NAJMAN ,  Didier SCHERRER ,  Noëlie CAMPOS ,  Aude GARCEL

    IPC分类号： A61K31/4709 ,  A61K31/497 ,  A61K31/498 ,  A61K31/47

    CPC分类号： A61K31/4709 ,  A61K31/47 ,  A61K31/497 ,  A61K31/498 ,  A61K31/506

    摘要： Methods for preventing or treating retroviral infection not HIV and/or for preventing, inhibiting or treating a disease caused by the retroviral infection include contacting a cell with compound (I) wherein: means a pyridazine, pyrimidine or pyrazine group, R independently represent a hydrogen atom, halogen atom or group chosen among a —CN, hydroxyl, —COOR1, (C1-C3)fluoroalkyl, (C1-C3)fluoroalkoxy, —NO2, —NR1R2, (C1-C4)alkoxy, phenoxy and (C1-C3)alkyl group, the alkyl being optionally mono-substituted by hydroxyl group, n is 1, 2 or 3, n′ is 1 or 2, R′ is a hydrogen atom, halogen atom or group chosen among (C1-C3)alkyl group, hydroxyl group, —COOR1 group, —NO2 group, —NR1R2 group, morpholinyl or morpholino group, N-methylpiperazinyl group, (C1-C3)fluoroalkyl group, (C1-C4)alkoxy group and —CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C.

    摘要翻译： 用于预防或治疗逆转录病毒感染而不是HIV和/或用于预防，抑制或治疗由逆转录病毒感染引起的疾病的方法包括使细胞与化合物（I）接触，其中：表示哒嗪，嘧啶或吡嗪基，R独立地表示氢 原子，卤素原子或选自-CN，羟基，-COOR1，（C1-C3）氟烷基，（C1-C3）氟烷氧基，-NO2，-NR1R2，（C1-C4）烷氧基，苯氧基和（C1-C3） ）烷基，烷基任选被羟基单取代，n为1,2或3，n'为1或2，R'为氢原子，卤素原子或选自（C1-C3）烷基中的基团 ，羟基，-COOR1基，-NO2基，-NR1R2基，吗啉基或吗啉基，N-甲基哌嗪基，（C1-C3）氟烷基，（C1-C4）烷氧基和-CN基，Z是N或 C，Y为N或C，X为N或C，W为N或C，T为N或C，U为N或C。