公开(公告)号：US20220348665A1

公开(公告)日：2022-11-03

申请号：US17616799

申请日：2020-06-15

Applicant: ABL Bio Inc.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Kyungjin PARK ,  Juhee KIM ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: C07K16/28 ,  C07K16/18 ,  A61P25/28

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20230357412A1

公开(公告)日：2023-11-09

申请号：US18063550

申请日：2022-12-08

Applicant: ABL BIO INC.

Inventor： Sungwon AN ,  Jinhyung AHN ,  Byungje SUNG ,  Dongin KIM ,  Daehae SONG ,  Jaehyun EOM ,  Yong-Gyu SON ,  Juhee KIM ,  Kyungjin PARK ,  Jinwon JUNG ,  Bora LEE ,  Hyesu YUN

IPC: A61P25/28 ,  C07K16/18 ,  C07K16/28

CPC classification number: C07K16/2863 ,  A61P25/28 ,  C07K16/18 ,  A61K2039/505

Abstract: The present disclosure relates to a bispecific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bispecific antibody for the prevention, treatment and / or diagnosis of synucleinopatheis associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.