公开(公告)号：US20240383983A1

公开(公告)日：2024-11-21

申请号：US18684660

申请日：2021-08-18

Applicant: ABL BIO, INC.

Inventor： Kyungjin PARK ,  Yangsoon LEE ,  Saeyi LIM ,  Kyeongsu PARK ,  Minkyu SEON ,  Wonjun SON ,  Hyejin CHUNG ,  Yeryoung YONG ,  Yong-Gyu SON ,  Yeunju KIM ,  Youngdon PAK

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: The present disclosure provides an anti-B7-H4/anti-4-1BB bispecific antibody capable to effectively block the T-cell inhibitory effect of B7-H4 on the surface of tumor cells, and simultaneously activate 4-1BB on T-cells. The bispecific antibody may have high binding affinity to both of a B7-H4 protein (e.g., a human, monkey and mouse B7-H4 protein) and a 4-1BB protein (e.g., a human, monkey and mouse 4-1BB protein). The present disclosure also provides an anti-B7-H4 antibody specifically binds to B7-H4 protein.

公开(公告)号：US20230279085A1

公开(公告)日：2023-09-07

申请号：US16759937

申请日：2018-11-16

Applicant: ABL Bio Inc.

Inventor： Sang Hoon LEE ,  Weonkyoo YOU ,  Jinhyung AHN ,  Sungwon AN ,  Jinwon JUNG ,  Bora LEE ,  Dongin KIM ,  Byungje SUNG ,  Yonggyu SON ,  Yeunju KIM ,  Jaehyun EOM ,  Seawon AHN ,  Youngdon PAK ,  Donghoon YEOM ,  Daehae SONG

IPC: C07K16/18 ,  G01N33/68 ,  A61P25/28

CPC classification number: C07K16/18 ,  G01N33/6896 ,  A61P25/28 ,  C07K2317/565 ,  C07K2317/567 ,  G01N2800/2821 ,  G01N2800/2835

Abstract: The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.

公开(公告)号：US20250066487A1

公开(公告)日：2025-02-27

申请号：US18935875

申请日：2024-11-04

Applicant: ABL Bio Inc. ,  YUHAN CORPORATION

Inventor： Yeryoung YONG ,  Ui-Jung JUNG ,  Hyejin CHUNG ,  Kyeongsu PARK ,  Wonjun SON ,  Yangsoon LEE ,  Yeunju KIM ,  Eunsil SUNG ,  Youngkwang KIM ,  Youngdon PAK ,  Minji PARK ,  Jaehyun EOM ,  Hyoju CHOI ,  Moo Young SONG ,  Na Rae LEE ,  Young Bong PARK ,  Eun-Jung LEE ,  Eun-Jung LEE

IPC: C07K16/28 ,  A61K39/00 ,  A61K39/395

Abstract: Provided are an anti-4-1BB/anti-EGFR bispecific antibody, and a pharmaceutical composition and a method for treating and/or preventing a cancer using the same.

公开(公告)号：US20240101687A1

公开(公告)日：2024-03-28

申请号：US18480071

申请日：2023-10-03

Applicant: ABL Bio Inc.

Inventor： Jinhyung AHN ,  Sungwon AN ,  Dongin KIM ,  Eunsil SUNG ,  Jaehyun EOM ,  Sang Hoon Lee ,  Weonkyoo YOU ,  Juhee KIM ,  Kyungjin PARK ,  Hyejin CHUNG ,  Jinwon JUNG ,  Bora LEE ,  Byungje SUNG ,  Yeunju KIM ,  Yong-Gyu SON ,  Seawon AHN ,  Daehae SONG ,  Jiseon YOO ,  Youngdon PAK ,  Donghoon YEOM ,  Yoseob LEE ,  Jaeho JUNG

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/18

CPC classification number: C07K16/2863 ,  A61K47/6845 ,  C07K16/18 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/567

Abstract: The present invention relates to a bi-specific antibody that specifically binds to alpha-synuclein and IGF1R, and an use of the bi-specific antibody for the prevention, treatment and/or diagnosis of synucleinopathies associated with alpha-synuclein or alpha-synuclein aggregates, and can allow the alpha-synuclein antibody or an antigen-binding fragment thereof to penetrate the blood brain barrier to exert its action in the brain, and extend the half-life to maintain the efficacy for a long time.

公开(公告)号：US20220363763A1

公开(公告)日：2022-11-17

申请号：US17269784

申请日：2019-08-21

Applicant: ABL BIO INC.

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Uijung JUNG ,  YoungKwang KIM ,  Yeun Ju KIM ,  Youngdon PAK ,  Sang Hoon LEE ,  Weon-Kyoo YOU ,  Jaeho JUNG ,  Lei FANG ,  Wenqing JIANG

IPC: C07K16/28 ,  A61P35/00

Abstract: The present disclosure provides an anti-PD-L1/anti-LAG3 bispecific antibody capable to effectively block the interactions between PD-L1 and its receptor PD-1 and between LAG3 and its ligand (e.g., a MHC class II molecule and FGL1). The bispecific antibody may have high binding affinity to both of a PD-L1 protein (e.g., a human PD-L1 protein) and a LAG3 protein (e.g., a human LAG3 protein). Also provided are antibodies and fragments that have specificity to the PD-L1 or LAG3 protein alone, or antibodies and fragments having additional specificity to one or more other antigens.

公开(公告)号：US20220242961A1

公开(公告)日：2022-08-04

申请号：US17296752

申请日：2019-12-02

Applicant: ABL Bio Inc.

Inventor： Eunyoung PARK ,  Yangsoon LEE ,  Hyejin CHUNG ,  Uijung JUNG ,  Youngdon PAK ,  Jun Hyun JEONG ,  Yeunju KIM ,  Seawon AHN ,  Byungje SUNG

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided is an anti-4-1 BB antibody or an antigen-binding fragment thereof, and uses thereof.