公开(公告)号：US20230227540A1

公开(公告)日：2023-07-20

申请号：US16475853

申请日：2018-01-05

Applicant: ABL Bio Inc.

Inventor： Jinhyung AHN ,  Sungwon AN ,  Dongin KIM ,  Eunsil SUNG ,  Jaehyun EOM ,  Sang Hoon LEE ,  Seung-Jae LEE ,  Tae Kyung KIM ,  Min Sun CHOI ,  Weonkyoo YOU ,  Jaeho JUNG ,  Juhee KIM ,  Jinwon JUNG ,  Yeunju KIM ,  Yonggyu SON ,  Byungje SUNG

IPC: C07K16/18 ,  A61P25/14 ,  G01N33/68

CPC classification number: C07K16/18 ,  A61P25/14 ,  G01N33/6896 ,  A61K2039/505 ,  C07K2317/565

Abstract: The disclosure discloses anti α-Syn antibodies preferentially recognizing α-Syn aggregates. The antibodies of the present invention bind to α-Syn aggregates with high affinity and specificity and inhibit accumulation or intercellular transfer of α-Syn aggregates, and thus can be used for detection, diagnosis and/or treatment or prevention of various diseases caused by the accumulation of α-Syn aggregates.