公开(公告)号：US11357788B2

公开(公告)日：2022-06-14

申请号：US16355545

申请日：2019-03-15

Applicant: ACADEMIA SINICA

Inventor： Hung-Chih Kuo ,  Yi-Ying Wu

IPC: A61K31/7105 ,  A61P25/16 ,  A61P25/28

Abstract: The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

公开(公告)号：US20190282605A1

公开(公告)日：2019-09-19

申请号：US16355545

申请日：2019-03-15

Applicant: ACADEMIA SINICA

Inventor： Hung-Chih Kuo ,  Yi-Ying Wu

IPC: A61K31/7105 ,  A61P25/28 ,  A61P25/16

Abstract: The present disclosure provides a method of reducing neurodegeneration and/or TDP43 associated aggregation, comprising knocking down the expression of Nuclear Paraspeckle Assembly Transcript 1 (NEAT1) or LncRNA NEAT1. Also provided are methods for screening a candidate agent that reduces neurodegeneration and/or TDP43 associated aggregation in a cell, treating or preventing a neurodegenerative disorder, delaying or preventing the onset of a neurodegenerative disorder or reducing a risk for developing a neurodegenerative disorder in a subject and determining whether a subject is suffering from, or at a risk of developing a neurodegenerative disorder, comprising measuring the presence of cytoplasmic NEAT1 in a biological sample, wherein the presence is indicative of the risk of developing a neurodegenerative disorder.

公开(公告)号：US11339405B2

公开(公告)日：2022-05-24

申请号：US15951114

申请日：2018-04-11

Applicant: Academia Sinica

Inventor： Hung-Chih Kuo ,  Ching-Yu Chuang ,  Chan-Hsien Yeh

IPC: C12N15/85 ,  G01N33/50 ,  C12N5/079 ,  A61K35/36 ,  C12N5/09 ,  C12N5/0793 ,  C12N5/0797 ,  A61K35/30 ,  C12N15/86 ,  C12N5/077

Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.