公开(公告)号：US10379045B2

公开(公告)日：2019-08-13

申请号：US14476191

申请日：2014-09-03

Applicant: Academia Sinica

Inventor： Pei-Kuen Wei ,  Kuang-Li Lee

IPC: G01N21/59

Abstract: The present invention provides a label-free sensing chip for identifying a chemical substance, comprising: (a) a transparent substrate comprising a base and first periodic ridges; and (b) a metal layer covering said transparent substrate, comprising second periodic ridges and third periodic ridges, in which said second periodic ridges has a height equal to or greater than the height of the first periodic ridges, and each ridge of the second periodic ridges fits into the space between each ridge of the first periodic ridges, and said third periodic ridges correspondingly located on said first periodic ridges. The present invention also provides a method for identifying a chemical substance by using the foresaid label-free sensing chip.

公开(公告)号：US12099009B2

公开(公告)日：2024-09-24

申请号：US17282163

申请日：2019-10-03

Applicant: ACADEMIA SINICA

Inventor： Pei-Kuen Wei ,  Ming-Yang Pan ,  Kuang-Li Lee

IPC: G01N21/552

CPC classification number: G01N21/553

Abstract: A method and apparatus for surface plasmon resonance imaging are provided for imaging the surface plasmon resonance signals caused by the interaction of biomolecules. In particular, the method and apparatus can image the slightly spectral change in a surface plasmon resonance mode by comparing the light intensities of two bands in the frequency domain of the surface plasmon.