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    Human iNKT cell activation using glycolipids with altered glycosyl groups
    1.
    发明授权
    Human iNKT cell activation using glycolipids with altered glycosyl groups 有权

    公开(公告)号：US10918714B2

    公开(公告)日：2021-02-16

    申请号：US16175504

    申请日：2018-10-30

    Applicant: Academia Sinica

    Inventor： Chi-Huey Wong ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Wu

    IPC: A61K39/39 ,  C07H15/18 ,  A61K39/00

    Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

    HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS
    3.
    发明申请
    HUMAN iNKT CELL ACTIVATION USING GLYCOLIPIDS WITH ALTERED GLYCOSYL GROUPS 有权
    使用具有改变的糖苷类的甘氨酸的人体神经细胞激活

    公开(公告)号：US20150071960A1

    公开(公告)日：2015-03-12

    申请号：US14480521

    申请日：2014-09-08

    Applicant: Academia Sinica

    Inventor： Chi-Huey WONG ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Chen

    IPC: A61K39/39 ,  C07H15/18

    CPC classification number: A61K39/39 ,  A61K2039/55511 ,  A61K2039/57 ,  C07H15/18

    Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

    Abstract translation: 提供了优先刺激人类不变NKT（iNKT）细胞的含有α-葡萄糖（α-Glc）的糖鞘糖脂（GSLs）。 公开了具有α-葡萄糖（α-Glc）的GSL，其具有比具有α-半乳糖（α-Gal）的细胞因子和趋化因子更强的诱导（但是在小鼠中较弱）和免疫细胞的膨胀和/或活化。 提供了带有α-葡萄糖（α-Glc）的GSL和α-Glc的衍生物，其中F在4和/或6位。 公开了通过具有α-Glc的GSL和其衍生物对iNKT独立诱导趋化因子的方法。 提供了使用具有α-Glc的GSL及其衍生物在人体中免疫刺激的方法。

    Human iNKT cell activation using glycolipids with altered glycosyl groups
    5.
    发明授权
    Human iNKT cell activation using glycolipids with altered glycosyl groups 有权

    公开(公告)号：US10111951B2

    公开(公告)日：2018-10-30

    申请号：US15689165

    申请日：2017-08-29

    Applicant: Academia Sinica

    Inventor： Chi-Huey Wong ,  Alice L. Yu ,  Kun-Hsien Lin ,  Tai-Na Wu

    IPC: A61K39/39 ,  C07H15/18 ,  A61K39/00

    Abstract: Glycosphingolipids (GSLs) bearing α-glucose (α-Glc) that preferentially stimulate human invariant NKT (iNKT) cells are provided. GSLs with α-glucose (α-Glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-Gal) are disclosed. GSLs bearing α-glucose (α-Glc) and derivatives of α-Glc with F at the 4 and/or 6 positions are provided. Methods for iNKT-independent induction of chemokines by the GSL with α-Glc and derivatives thereof are disclosed. Methods for immune stimulation in humans using GSLs with α-Glc and derivatives thereof are provided.

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