公开(公告)号：US20220206014A1

公开(公告)日：2022-06-30

申请号：US17611155

申请日：2020-05-12

Applicant: ACADEMIA SINICA

Inventor： Wen-Chin YANG ,  Meng-Ting YANG

IPC: G01N33/68 ,  G01N33/543

Abstract: The invention relates to LAMA2, PLXDC2 and MLL4 as novel biomarkers for prediabetes and diabetes. Specifically, use of a set of probes with specific binding affinities to prediabetes and diabetes protein markers comprising MLL4, LAMA2 and PLXDC2 for screening prediabetes and diabetes for care and/or treatment is disclosed. The set of probes comprises a first probe, a second probe and a third probe having specific binding affinities to the MLL4, LAMA2, and PLXDC2, respectively. A diagnostic kit device/apparatus comprising a set of probes is disclosed. A method for detecting and identifying prediabetes and/or diabetes in a subject in need thereof is also disclosed. The subject in need thereof identified as having prediabetes or diabetes is subject to a care and/or a treatment regime for the prediabetes or diabetes. Also disclosed is a method for identifying prediabetes and/or diabetes protein markers.