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    PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ß-CELL PATHOGENESIS AND TREATING DIABETES
    1.
    发明申请
    PDIA4 INHIBITORS AND USE THEREOF FOR INHIBITING ß-CELL PATHOGENESIS AND TREATING DIABETES 有权

    公开(公告)号：US20230046445A1

    公开(公告)日：2023-02-16

    申请号：US17780482

    申请日：2020-11-15

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG ,  Keng-Chang TSAI

    IPC: A61K31/216 ,  A61K31/196 ,  A61P3/10

    Abstract: Disulfide-Isomerase A4 (PDIA4) inhibitors and use thereof for inhibiting pancreatic β-cell pathogenesis and treating diabetes are disclosed. Drug candidates that inhibit PDIA4 with IC50 values ranging from 4 μM to 300 nM are identified. The compounds are highly active in augmenting insulin secretion from pancreatic β-cells. The representative compound No. 8 (4,5-dimethoxy-2-propiolamidobenzoic acid), alone or in combination with metformin, is effective in preserving pancreatic β-cell function, treating and/or reversing, returning blood glucose concentration to a normal level in a diabetic.

    BENEFICIAL EFFECT OF BIDENS PILOSA ON FAT DECREASE AND MUSCLE INCREASE
    3.
    发明申请
    BENEFICIAL EFFECT OF BIDENS PILOSA ON FAT DECREASE AND MUSCLE INCREASE 审中-公开

    公开(公告)号：US20190000904A1

    公开(公告)日：2019-01-03

    申请号：US16068125

    申请日：2017-01-11

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG ,  Lee-Tian CHANG ,  Yu-Chuan LIANG

    IPC: A61K36/28 ,  A61K31/7028 ,  A61P3/04 ,  A23L33/105 ,  A23K20/105

    Abstract: A composition comprising a therapeutically effective amount of Bidens pilosa extract, or an active compound isolated from the Bidens pilosa extract for use in treating obesity, reducing body weight or body weight gain, and/or gaining muscle mass or muscle content in a subject in need thereof is disclosed. The composition is useful for reducing fat cell size and/or fat accumulation in the fat cell in a subject in need thereof. The composition may further comprises an animal feed. A polyacetylenic compound for use in treating obesity, gaining muscle mass or muscle content, and/or increasing lean tissue protein content in a subject in need thereof is also disclosed. In one embodiment, the polyacetylenic compound is cytopiloyne.

    ANTI-COCCIDIAL PHYTOGENIC FORMULATIONS
    5.
    发明申请
    ANTI-COCCIDIAL PHYTOGENIC FORMULATIONS 有权

    公开(公告)号：US20220257684A1

    公开(公告)日：2022-08-18

    申请号：US17628191

    申请日：2020-07-18

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG

    IPC: A61K36/282 ,  A61K36/28 ,  A61K31/216 ,  A61P33/02 ,  A61K9/00 ,  A23K10/30 ,  A23K50/75

    Abstract: The present invention relates to anti-coccidial phytogenic formulations. Specifically, anti-coccidial compositions and use thereof are disclosed. An anti-coccidial composition comprises (a) an effective amount of Artemisia indica extract; and (b) an effective amount of Bidens pilosa extract. The composition may further comprise a pharmaceutically acceptable vehicle, excipient, or carrier, and/or an animal feed. The anti-coccidial compositions may be used in the manufacture of a medicament for killing coccidian oocysts, inhibiting oocyst sporulation, reducing sporozoite invasion, and lessening bloody stools, or for alleviating or treating coccidiosis, in a subject in need thereof. In another aspect, the invention relates to use of an anti-coccidial formulation comprising an effective amount of Artemisia indica extract, and a pharmaceutical acceptable vehicle in the manufacture of a medicament for killing coccidian oocysts and inhibiting coccidian oocyst sporulation, and sporozoite invasion.

    LAMA2, PLXDC2 AND MLL4 AS NOVEL BIOMARKERS FOR PREDIABETES AND DIABETES
    8.
    发明申请
    LAMA2, PLXDC2 AND MLL4 AS NOVEL BIOMARKERS FOR PREDIABETES AND DIABETES 有权

    公开(公告)号：US20220206014A1

    公开(公告)日：2022-06-30

    申请号：US17611155

    申请日：2020-05-12

    Applicant: ACADEMIA SINICA

    Inventor： Wen-Chin YANG ,  Meng-Ting YANG

    IPC: G01N33/68 ,  G01N33/543

    Abstract: The invention relates to LAMA2, PLXDC2 and MLL4 as novel biomarkers for prediabetes and diabetes. Specifically, use of a set of probes with specific binding affinities to prediabetes and diabetes protein markers comprising MLL4, LAMA2 and PLXDC2 for screening prediabetes and diabetes for care and/or treatment is disclosed. The set of probes comprises a first probe, a second probe and a third probe having specific binding affinities to the MLL4, LAMA2, and PLXDC2, respectively. A diagnostic kit device/apparatus comprising a set of probes is disclosed. A method for detecting and identifying prediabetes and/or diabetes in a subject in need thereof is also disclosed. The subject in need thereof identified as having prediabetes or diabetes is subject to a care and/or a treatment regime for the prediabetes or diabetes. Also disclosed is a method for identifying prediabetes and/or diabetes protein markers.

    BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA
    9.
    发明申请
    BIDENS PILOSA AND ITS PHYTOCHEMICALS FOR USE IN PREVENTION AND TREATMENT OF DIARRHEA 有权

    公开(公告)号：US20220174986A1

    公开(公告)日：2022-06-09

    申请号：US17598284

    申请日：2020-03-22

    Applicant: Academia Sinica

    Inventor： Wen-Chin YANG ,  Yu-Chuar LIANG

    IPC: A23K10/30 ,  A23K50/30 ,  A61K36/28

    Abstract: A composition comprising Bidens pilosa or an active compound isolated from the Bidens pilosa for use in treating, inhibiting and/or decreasing the presence of pathogenic gut microbiota in an animal in need thereof is disclosed. The pathogenic gut microbiota are at least one selected from the group consisting of Brachyspira, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis coronavirus (TGEV) and Rotavirus (RV). The composition is also for use in treating, inhibiting and/or decreasing occurrence of swine diarrhea, swine dysentery, swine viral infection and increasing the percentage of swine carcass and bone weight. In one embodiment, the composition is for use in treating, inhibiting and/or decreasing occurrence of swine dysentery associated with Brachyspira.

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