公开(公告)号：US20230233699A1

公开(公告)日：2023-07-27

申请号：US17918947

申请日：2021-04-15

Applicant: ACADEMIA SINICA

Inventor： Andrew H.-J. WANG ,  Cheng-Chung LEE ,  Nai-Shu HSU ,  Wen-Chih KUO

IPC: A61K47/68 ,  A61K47/58 ,  A61K47/54

CPC classification number: A61K47/6803 ,  A61K47/58 ,  A61K47/6889 ,  A61K47/549

Abstract: The present invention relates to oligonucleotide conjugates and preparation and applications thereof. In particular, the present invention relates to an oligonucleotide conjugated to a biomolecule (e.g. an antibody) and/or an agent of interest (e.g. a drug). In certain embodiments, the oligonucleotide of the present invention is a hybridized complex of a single strand oligonucleotide carrying a biomolecule and a complementary strand oligonucleotide bearing an agent of interest where the hybridized nucleotide segment acts as a linker to link the biomolecule and the agent of interest in one molecule.