公开(公告)号：US11369690B2

公开(公告)日：2022-06-28

申请号：US16111250

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Steven R Roffler ,  Tian-Lu Cheng ,  Chien-Han Kao ,  Bing-Mae Chen ,  Yu-Cheng Su ,  Hsin-Yi Tung ,  Kuo-Hsiang Chuang

IPC: C07K16/00 ,  A61K39/00 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32 ,  A61K39/395 ,  C07K16/28 ,  C07K16/26 ,  A61K47/14 ,  A61K47/69 ,  A61K45/06

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US11040111B2

公开(公告)日：2021-06-22

申请号：US16111242

申请日：2018-08-24

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Steven R Roffler ,  Tian-Lu Cheng ,  Chien-Han Kao ,  Bing-Mae Chen ,  Yu-Cheng Su ,  Hsin-Yi Tung ,  Kuo-Hsiang Chuang

IPC: C07K16/00 ,  A61K47/68 ,  C07K16/44 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28 ,  A61K49/00 ,  A61K47/69 ,  A61K39/395 ,  A61K47/60 ,  A61K39/00

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppressing the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

公开(公告)号：US10188742B2

公开(公告)日：2019-01-29

申请号：US15123243

申请日：2015-03-02

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： Steven R Roffler ,  Tian-Lu Cheng ,  Chien-Han Kao ,  Bing-Mae Chen ,  Yu-Cheng Su ,  Hsin-Yi Tung ,  Kuo-Hsiang Chuang

IPC: C07K16/00 ,  A61K39/00 ,  A61K47/48 ,  A61K49/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/44 ,  A61K47/68

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.