公开(公告)号：US20170252421A1

公开(公告)日：2017-09-07

申请号：US15506948

申请日：2015-08-28

申请人： ACADEMISCH MEDISCH CENTRUM ,  WAGENINGEN UNIVERSITEIT

发明人： Max NIEUWDORP ,  Willem Meindert DE VOS

IPC分类号： A61K39/02 ,  C07K16/12

CPC分类号： A61K39/0208 ,  A61K2039/505 ,  A61K2039/542 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K16/1203 ,  C07K2317/76

摘要： Compounds disclosed herein are effective against Ralstonia pickettii for treating or preventing insulin resistance, obesity or type II diabetes of a subject, and include an antibiotic effective against Ralstonia pickettii, an immunogenic compound producing a protective immune response, or an antibody which specifically binds to Ralstonia pickettii or a fragment thereof. In vitro methods for diagnosis or prediction of insulin resistance, obesity or type II diabetes include determining the presence of Ralstonia pickettii or of an antibody which specifically binds to Ralstonia pickettii in a test sample. An antibody binding specifically to an antigen of Ralstonia pickettii, a Ralstonia pickettii cell, or a nucleic acid hybridizing under stringent conditions to a nucleic acid from Ralstonia pickettii is disclosed. A kit including said antibody, the nucleic acid, and optionally a Ralstonia pickettii bacteria or a nucleic acid or protein thereof, a further reagent or a conventional kit component, is also disclosed.