公开(公告)号：US20220280640A1

公开(公告)日：2022-09-08

申请号：US17731671

申请日：2022-04-28

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher B. FOX

IPC: A61K39/39 ,  A61K35/76 ,  A61K39/04 ,  A61K39/12 ,  A61K45/06 ,  A61P31/06 ,  A61P31/12 ,  A61P33/04 ,  A61P35/00 ,  C07K14/705

Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.

公开(公告)号：US20230293440A1

公开(公告)日：2023-09-21

申请号：US18180801

申请日：2023-03-08

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher B. FOX ,  Thomas VEDVICK ,  Lucien BARNES, V ,  Ryan M. KRAMER ,  Steven G. REED

IPC: A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10

CPC classification number: A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K2039/55572 ,  A61K2039/552 ,  A61K2039/55511

Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.

公开(公告)号：US20220257754A1

公开(公告)日：2022-08-18

申请号：US17731718

申请日：2022-04-28

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher B. FOX

IPC: A61K39/39 ,  A61K39/04 ,  A61K39/12 ,  C07K14/705 ,  A61K35/76 ,  A61K45/06 ,  A61P31/12 ,  A61P33/04 ,  A61P31/06 ,  A61P35/00

Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.