公开(公告)号：US20230293440A1

公开(公告)日：2023-09-21

申请号：US18180801

申请日：2023-03-08

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher B. FOX ,  Thomas VEDVICK ,  Lucien BARNES, V ,  Ryan M. KRAMER ,  Steven G. REED

IPC: A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10

CPC classification number: A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K2039/55572 ,  A61K2039/552 ,  A61K2039/55511

Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.

公开(公告)号：US20230116042A1

公开(公告)日：2023-04-13

申请号：US17960110

申请日：2022-10-04

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher FOX ,  Steven G. REED ,  Susan BALDWIN ,  Thomas VEDVICK

IPC: A61K9/113 ,  A61K39/00 ,  A61K9/107 ,  A61K39/39 ,  A61K39/12 ,  A61K47/06 ,  A61K47/24 ,  A61K39/015 ,  A61K47/26

Abstract: Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emusion is greater than about 9.