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公开(公告)号:US11801223B2
公开(公告)日:2023-10-31
申请号:US15108773
申请日:2014-12-29
Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE
Inventor: Christopher B. Fox , Thomas Vedvick , Lucien Barnes V. , Ryan M. Kramer , Steven G. Reed
CPC classification number: A61K9/19 , A61K39/00 , A61K39/04 , A61K39/39 , A61K47/10 , A61K47/22 , A61K47/26 , A61K2039/552 , A61K2039/55511 , A61K2039/55572
Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.
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公开(公告)号:US12201722B2
公开(公告)日:2025-01-21
申请号:US17470874
申请日:2021-09-09
Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE
Inventor: Christopher B. Fox , Amit Praful Khandhar , Neal Van Hoeven , Jesse H. Erasmus , Susan S. Lin
Abstract: Provided herein are nanostructured lipid carrier compositions, and methods of making and using thereof. The compositions comprise a nanostructured lipid carrier (NLC), where the NLC comprises an oil core comprising a mixture of a liquid phase lipid and a solid phase lipid, a cationic lipid, a sorbitan ester, and a hydrophilic surfactant, and optionally a bioactive agent. The bioactive agent can be associated with the NLC. The compositions are capable of delivery of a biomolecule to a cell for the generation of an immune response, for example, for vaccine, therapeutic, or diagnostic uses. Compositions and methods related to making the compositions and using the compositions for stimulating an immune response are also provided.
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公开(公告)号:US11344619B2
公开(公告)日:2022-05-31
申请号:US16098615
申请日:2017-05-11
Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE
Inventor: Christopher B. Fox
IPC: A61K39/395 , A61K39/39 , A61K39/04 , A61K39/12 , C07K14/705 , A61K35/76 , A61K45/06 , A61P31/12 , A61P33/04 , A61P31/06 , A61P35/00 , A61K39/00
Abstract: Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.
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