公开(公告)号：US11801223B2

公开(公告)日：2023-10-31

申请号：US15108773

申请日：2014-12-29

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher B. Fox ,  Thomas Vedvick ,  Lucien Barnes V. ,  Ryan M. Kramer ,  Steven G. Reed

IPC: A61K9/19 ,  A61K39/00 ,  A61K47/26 ,  A61K39/04 ,  A61K39/39 ,  A61K47/22 ,  A61K47/10

CPC classification number: A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55572

Abstract: The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.

公开(公告)号：US11510875B2

公开(公告)日：2022-11-29

申请号：US14377488

申请日：2013-02-07

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher Fox ,  Steven G. Reed ,  Susan Baldwin ,  Thomas Vedvick

IPC: A61K9/113 ,  A61K39/39 ,  A61K39/015 ,  A61K39/12 ,  A61K9/107 ,  A61K47/06 ,  A61K39/00 ,  A61K47/24 ,  A61K47/26

Abstract: Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emulsion is greater than about 9.