公开(公告)号：US20230287038A1

公开(公告)日：2023-09-14

申请号：US18020253

申请日：2021-06-04

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Yizhi QI ,  Christopher Bradford FOX

IPC: C07J63/00 ,  A61K39/39 ,  G01N30/86 ,  G01N30/72 ,  B01D15/30 ,  B01D15/32

CPC classification number: C07J63/008 ,  A61K39/39 ,  G01N30/8631 ,  G01N30/72 ,  B01D15/305 ,  B01D15/325 ,  A61K2039/55577

Abstract: Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.