公开(公告)号：US20230287038A1

公开(公告)日：2023-09-14

申请号：US18020253

申请日：2021-06-04

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Yizhi QI ,  Christopher Bradford FOX

IPC: C07J63/00 ,  A61K39/39 ,  G01N30/86 ,  G01N30/72 ,  B01D15/30 ,  B01D15/32

CPC classification number: C07J63/008 ,  A61K39/39 ,  G01N30/8631 ,  G01N30/72 ,  B01D15/305 ,  B01D15/325 ,  A61K2039/55577

Abstract: Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.

公开(公告)号：US20240050561A1

公开(公告)日：2024-02-15

申请号：US18269284

申请日：2021-10-16

Applicant: ACCESS TO ADVANCED HEALTH INSTITUTE

Inventor： Christopher Bradford FOX

IPC: A61K39/39 ,  A61K39/145 ,  A61K47/22 ,  A61K9/107 ,  A61P37/04

CPC classification number: A61K39/39 ,  A61K39/145 ,  A61K47/22 ,  A61K9/1075 ,  A61P37/04 ,  A61K2039/55566

Abstract: This disclosure describes the use of solanesol as an adjuvant in vaccine compositions, as well as related prophylactic and therapeutic methods. Solanesol may be used to replace squalene in vaccine compositions with similar or superior immunostimulatory effects. Solanesol, which is solid at room temperature, may be formulated for use in vaccine compositions by heating above its melting temperature in an aqueous solution to form a dispersion.