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公开(公告)号：US20210008051A1
公开(公告)日：2021-01-14
申请号：US17028872
申请日：2020-09-22
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409 , A61K9/20 , A61K31/435 , A61K31/44
摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
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公开(公告)号：US20190314350A1
公开(公告)日：2019-10-17
申请号：US16453639
申请日：2019-06-26
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409 , A61K31/44 , A61K31/435 , A61K9/20
摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
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公开(公告)号：US20190247378A1
公开(公告)日：2019-08-15
申请号：US16393586
申请日：2019-04-24
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409
摘要： Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a demyelinating condition, such as MS.
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公开(公告)号：US20180277256A1
公开(公告)日：2018-09-27
申请号：US15996338
申请日：2018-06-01
发明人： Ron Cohen , Andrew R. Blight , Lawrence Marinucci
CPC分类号： G16H50/70 , G06F19/3481 , G06Q50/24 , G16H10/20 , G16H10/60
摘要： A process for determining responders in clinical testing environments that involves, inter alia, detecting treatment response through the use of small numbers of measurements of randomly varying outcome variables in individual clinical trial subjects, and by analyzing the measurements in such a way as to eliminate troublesome variables, such as a spontaneous population variability.
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5.发明申请METHODS FOR TREATING SENSORIMOTOR IMPAIRMENTS ASSOCIATED WITH CERTAIN TYPES OF STROKE USING AMINOPYRIDINES 审中-公开治疗与某些类型的使用氨基吡啶类型的传感器损伤相关的方法公开(公告)号：US20160058743A1
公开(公告)日：2016-03-03
申请号：US14784279
申请日：2014-04-14
IPC分类号： A61K31/4409 , A61K9/20
CPC分类号： A61K31/4409 , A61K9/20 , A61P9/10 , A61P25/00
摘要： Disclosed herein are methods and compositions related to therapeutic use of aminopyridines in patients with stroke-related impairments, in particular, in patients with sensorimotor impairments resulting from certain types of stroke.
摘要翻译： 本文公开了与中风相关损伤患者，特别是在由某些类型的中风引起的感觉运动障碍的患者中治疗性使用氨基吡啶有关的方法和组合物。
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公开(公告)号：US20170273960A1
公开(公告)日：2017-09-28
申请号：US15482432
申请日：2017-04-07
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409 , A61K9/20 , A61K31/435 , A61K31/44
摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
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7.发明申请公开(公告)号：US20170035742A1
公开(公告)日：2017-02-09
申请号：US15331713
申请日：2016-10-21
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409
摘要： Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a demyelinating condition, such as MS.
摘要翻译： 本文公开了与持续使用氨基吡啶如4-氨基吡啶相关的方法和组合物，以改善患有脱髓鞘状况的患者如MS的损伤。
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公开(公告)号：US20160184286A1
公开(公告)日：2016-06-30
申请号：US15064574
申请日：2016-03-08
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409
摘要： Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a demyelinating condition, such as MS.
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公开(公告)号：US20150080436A1
公开(公告)日：2015-03-19
申请号：US14531191
申请日：2014-11-03
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409 , A61K9/20 , A61K31/435 , A61K31/44
摘要： A pharmaceutical composition which comprises a therapeutically effective amount of a aminopyridine dispersed in a release matrix, including, for example, a composition that can be formulated into a stable, sustained-release oral dosage formulation, such as a tablet which provides, upon administration to a patient, a therapeutically effective plasma level of the aminopyridine for a period of at about 12 hours and the use of the composition to treat various neurological diseases, including multiple sclerosis. A method of selecting individuals based on responsiveness to a treatment, including, for example, identifying individuals who responded to treatment with a sustained release fampridine composition.
摘要翻译： 一种药物组合物，其包含分散在释放基质中的治疗有效量的氨基吡啶，包括例如可配制成稳定的持续释放口服剂量制剂的组合物，例如片剂，其在给药至 患者，氨基吡啶的治疗有效血浆水平约12小时，以及使用该组合物治疗各种神经疾病，包括多发性硬化。 基于对治疗的反应性来选择个体的方法，包括例如鉴定用持续释放的芬太尼组合物治疗反应的个体。
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10.发明申请公开(公告)号：US20140206728A1
公开(公告)日：2014-07-24
申请号：US14222535
申请日：2014-03-21
发明人： Andrew R. Blight , Ron Cohen
IPC分类号： A61K31/4409
CPC分类号： A61K31/4409
摘要： Disclosed herein are methods and compositions related to the durable use of aminopyridines, such as 4-aminopyridine, to improve impairments of patients with a demyelinating condition, such as MS.
摘要翻译： 本文公开了与持续使用氨基吡啶如4-氨基吡啶相关的方法和组合物，以改善患有脱髓鞘状况的患者如MS的损伤。
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