公开(公告)号：US20230097090A1

公开(公告)日：2023-03-30

申请号：US17634516

申请日：2020-08-14

申请人： ACUITAS THERAPEUTICS, INC.

发明人： Ying K. TAM ,  Paulo Jia Ching LIN ,  Sean SEMPLE ,  Christopher J. BARBOSA

IPC分类号： A61K9/51 ,  C07C235/08 ,  A61K31/7105

摘要： Lipid nanoparticles having improved properties are provided. Use of the lipid nanoparticles for delivery of a therapeutic agent to primates for treatment of various indications is also described.

公开(公告)号：US20210251898A1

公开(公告)日：2021-08-19

申请号：US17142731

申请日：2021-01-06

申请人： CureVac AG ,  Acuitas Therapeutics Inc.

发明人： Patrick BAUMHOF ,  Mariola FOTIN-MLECZEK ,  Regina HEIDENREICH ,  Michael J. HOPE ,  Edith JASNY ,  Sandra LAZZARO ,  Paulo Jia Ching LIN ,  Johannes LUTZ ,  Barbara MUI ,  Benjamin PETSCH ,  Susanne RAUCH ,  Kim Ellen SCHMIDT ,  Ying TAM

IPC分类号： A61K9/127 ,  A61K47/69 ,  A61P37/02 ,  A61P31/16 ,  A61K9/19 ,  A61K31/7105 ,  A61K39/145 ,  A61K39/39 ,  A61K47/14 ,  A61K31/16 ,  A61K31/23 ,  A61K31/40

摘要： The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.

公开(公告)号：US20200163878A1

公开(公告)日：2020-05-28

申请号：US16345299

申请日：2017-10-26

申请人： CureVac AG ,  Acuitas Therapeutics Inc.

发明人： Patrick BAUMHOF ,  Mariola FOTIN-MLECZEK ,  Regina HEIDENREICH ,  Michael J. HOPE ,  Edith JASNY ,  Sandra LAZZARO ,  Paulo Jia Ching LIN ,  Johannes LUTZ ,  Barbara MUI ,  Benjamin PETSCH ,  Susanne RAUCH ,  Kim Ellen SCHWENDT ,  Ying TAM

IPC分类号： A61K9/127 ,  A61K39/39 ,  A61K9/19 ,  A61P37/02 ,  A61K31/7105 ,  A61P31/16 ,  A61K39/145 ,  A61K47/69 ,  A61K47/14

摘要： The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.