专利检索 ap:("ADIMAB, LLC") AND inv:"Robert PEJCHAL" 第 1 页

1.

发明申请
HIGH AFFINITY ANTI-CD3 ANTIBODIES, AND METHODS FOR THEIR GENERATION AND USE 有权

公开(公告)号：US20230002487A1

公开(公告)日：2023-01-05

申请号：US17617046

申请日：2020-06-08

申请人： ADIMAB, LLC

发明人： Robert PEJCHAL , Caitlin STEIN , Julia McCREARY

IPC分类号： C07K16/28

摘要： Antibodies and antigen-binding fragments thereof with high affinity for CD3 and desirable developability profiles are provided, as well as methods for their manufacture and use.

2.

发明申请
ENGINEERED PH-DEPENDENT ANTI-CD3 ANTIBODIES, AND METHODS FOR THEIR GENERATION AND USE 有权

公开(公告)号：US20220380463A1

公开(公告)日：2022-12-01

申请号：US17617019

申请日：2020-06-08

申请人： ADIMAB, LLC

发明人： James GEOGHEGAN , Bianka PRINZ , Robert PEJCHAL

IPC分类号： C07K16/28

摘要： Engineered pH-dependent anti-CD3 binding domains and antibodies and/or antigen-binding domains comprising same, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use.