公开(公告)号：US11542330B2

公开(公告)日：2023-01-03

申请号：US16611832

申请日：2018-05-08

申请人： Adimab, LLC

发明人： Laura M. Walker ,  Robert Pejchal ,  Eric Krauland ,  Maximiliano Vasquez ,  Monica Wai Ling Leung

IPC分类号： C07K16/28

摘要： Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use. Reagents for identifying, isolating, selecting, generating and characterizing CD3 binding domains and antibodies comprising them are also provided.

公开(公告)号：US20220396622A1

公开(公告)日：2022-12-15

申请号：US17848808

申请日：2022-06-24

申请人： ADIMAB, LLC

发明人： Robert Pejchal ,  Eric Krauland ,  Maximiliano Vasquez ,  Michael Brown ,  Anthony Cooper

IPC分类号： C07K16/28

摘要： The present invention provides Fc variants and polypeptides, e.g., antibodies and Fc fusion proteins, comprising such Fc variants. In particular, Fc variants with diminished effector function as a consequence of hinge region and CH2 domain mutations, e.g., LALE-PG, are provided. Such variants maintain antigen-binding and favorable developability profiles and may display improved expressability.

公开(公告)号：US11485794B2

公开(公告)日：2022-11-01

申请号：US16864577

申请日：2020-05-01

申请人： Merck Sharp & Dohme Corp. ,  Adimab, LLC

发明人： Zhu Chen ,  Kenneth Ellsworth ,  James Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Bianka Prinz

IPC分类号： C07K16/36 ,  A61K39/395 ,  A61K39/00

摘要： Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.

公开(公告)号：US11312761B2

公开(公告)日：2022-04-26

申请号：US16343297

申请日：2017-10-20

申请人： Adimab, LLC

发明人： Laura M. Walker

IPC分类号： C07K16/10 ,  A61P31/16 ,  A61K9/00 ,  A61K39/12 ,  C12N15/85 ,  A61K45/06

摘要： Anti-RSV antibodies with neutralizing potency against RSV subtype A and RSV subtype B are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.

公开(公告)号：US10889811B2

公开(公告)日：2021-01-12

申请号：US16126987

申请日：2018-09-10

申请人： Adimab, LLC

发明人： Maximiliano Vasquez ,  Arvind Sivasubramanian ,  Michael Feldhaus

IPC分类号： C40B50/06 ,  C12N15/10 ,  C07K16/00 ,  G01N33/543 ,  C40B40/08 ,  G16B35/00 ,  G16C20/60

摘要： The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed sequence and length diversity.

公开(公告)号：US20200255542A1

公开(公告)日：2020-08-13

申请号：US16864583

申请日：2020-05-01

申请人： Merck Sharp & Dohme Corp. ,  Adimab, LLC

发明人： Zhu Chen ,  Kenneth Ellsworth ,  James Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Vaishnavi Ganti ,  Mohammad Tabrizifard ,  Bianka Prinz

IPC分类号： C07K16/36 ,  A61K39/395

摘要： Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.

公开(公告)号：US10584179B2

公开(公告)日：2020-03-10

申请号：US16101861

申请日：2018-08-13

申请人： Merck Sharp & Dohme Corp. ,  Adimab, LLC

发明人： Zhu Chen ,  Kenneth P. Ellsworth ,  James A. Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Vaishnavi Ganti ,  Mohammad Tabrizifard ,  Bianka Prinz

IPC分类号： C07K16/36 ,  A61K39/395 ,  A61P7/02 ,  C07K16/30 ,  C07K14/745 ,  A61K39/00

摘要： Antibodies that bind the apple 2 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa are described.

公开(公告)号：US20190382474A1

公开(公告)日：2019-12-19

申请号：US16362457

申请日：2019-03-22

申请人： Surface Oncology, Inc. ,  Adimab LLC

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY

IPC分类号： C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68 ,  A61P35/00

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20190284295A1

公开(公告)日：2019-09-19

申请号：US16352589

申请日：2019-03-13

申请人： Surface Oncology, Inc. ,  Adimab, LLC

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/85

摘要： The present disclosure relates to anti-CD39 antibodies, and antigen binding portions thereof and their use in treating cancer.

公开(公告)号：US20180362661A1

公开(公告)日：2018-12-20

申请号：US16101861

申请日：2018-08-13

申请人： Merck Sharp & Dohme Corp. ,  Adimab, LLC

发明人： Zhu Chen ,  Kenneth Ellsworth ,  James A. Milligan ,  Elizabeth Oldham ,  Dietmar Seiffert ,  Vaishnavi Ganti ,  Mohammad Tabritzifard ,  Bianka Prinz

IPC分类号： C07K16/36 ,  A61K39/395 ,  A61P7/02 ,  C07K16/30 ,  C07K14/745 ,  A61K39/00

摘要： Antibodies that bind the apple 2 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa are described.