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公开(公告)号：US20180118807A1
公开(公告)日：2018-05-03
申请号：US15842178
申请日：2017-12-14
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/31 , C07K14/74 , C07K14/435 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2 X3 X4 AX6 X7 EIRWLPNL X16X17 X18 QRX21 AFIX25 X26LX28 X29. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US11633507B2
公开(公告)日：2023-04-25
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US09975943B2
公开(公告)日：2018-05-22
申请号：US14776319
申请日：2014-03-17
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/74 , C07K14/31 , C07K14/435 , A61K38/00
CPC classification number: C07K14/745 , A61K38/00 , C07K14/31 , C07K14/435 , C07K14/70535 , C07K14/70539 , C07K2319/74
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US20160199521A1
公开(公告)日：2016-07-14
申请号：US15083424
申请日：2016-03-29
Applicant: General Electric Company , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
IPC: A61K51/08
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
Abstract translation: 包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。
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公开(公告)号：US20160031967A1
公开(公告)日：2016-02-04
申请号：US14776319
申请日：2014-03-17
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745
CPC classification number: C07K14/745 , A61K38/00 , C07K14/31 , C07K14/435 , C07K14/70535 , C07K14/70539 , C07K2319/74
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2X3X4AX6X7 EIRWLPNL X16X17X18QRX21 AFIX25X26LX28X29 (SEQ ID NO: 1075). The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
Abstract translation: 本公开涉及对新生儿Fc受体具有结合亲和力的一类工程化多肽（在下文中称为FcRn），并提供包含序列EX2X3X4AX6X7EIRWLPNL X16X17X18QRX21AFIX25X26LX28X29（SEQ ID NO：1075）的FcRn结合多肽。 本公开还涉及这种FcRn结合多肽作为用于改变药代动力学和药效学性质的试剂以及作为治疗剂的用途。
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Patent Agency Ranking
公开(公告)号：US10894097B2
公开(公告)日：2021-01-19
申请号：US16145115
申请日：2018-09-27
Applicant: GENERAL ELECTRIC COMPANY , AFFIBODY AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US20160108095A1
公开(公告)日：2016-04-21
申请号：US14955647
申请日：2015-12-01
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Lars Abrahmsen
IPC: C07K14/315 , A61K47/48
CPC classification number: C07K14/315 , A61K38/00 , A61K51/081 , C07K14/001 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/70 , Y02A50/473
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
Abstract translation: 本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。 它还涉及利用这些和其它化合物在不同背景下结合白蛋白的新方法和用途，其中一些对于包括人在内的哺乳动物的疾病的治疗或诊断具有重要意义。
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公开(公告)号：US20240139352A1
公开(公告)日：2024-05-02
申请号：US18119070
申请日：2023-03-08
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
CPC classification number: A61K51/088 , C07K14/71
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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公开(公告)号：US10329331B2
公开(公告)日：2019-06-25
申请号：US14955647
申请日：2015-12-01
Applicant: Affibody AB
Inventor： Caroline Ekblad , Lars Abrahmsen
IPC: C07K14/315 , C07K14/00 , A61K51/08 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
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公开(公告)号：US20210170057A1
公开(公告)日：2021-06-10
申请号：US17117697
申请日：2020-12-10
Applicant: General Electric Company , Affibody AB
Inventor： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Simonsson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
Abstract: Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
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