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公开(公告)号：US11505576B2
公开(公告)日：2022-11-22
申请号：US16977625
申请日：2019-03-12
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Sophia Hober , Sarah Lindbo
Abstract: The disclosure provides a population of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence Xsc1AELDXsc2Xsc3GVG AXXIKXIXsc4XA XXVEXVQXXK QXILAX. The disclosure also provides methods for selecting and identifying polypeptides from the population, as well as such polypeptides themselves.
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公开(公告)号：US20190284241A1
公开(公告)日：2019-09-19
申请号：US16377722
申请日：2019-04-08
Applicant: Affibody AB
Inventor： Lars Abrahmsén , Caroline Ekblad , Elin Gunneriusson , Torbjörn Gräslund , Johan Seijsing , John Löfblom , Malin Lindborg , Fredrik Frejd , Lindvi Gudmundsdotter
IPC: C07K14/00 , C07K14/735 , C07K14/74 , C07K14/31
Abstract: The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US20180118807A1
公开(公告)日：2018-05-03
申请号：US15842178
申请日：2017-12-14
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Malin Lindborg , Lars Abrahmsen , John Löfblom , Torbjörn Gräslund , Johan Seijsing
IPC: C07K14/745 , C07K14/735 , C07K14/31 , C07K14/74 , C07K14/435 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for the neonatal Fc receptor (in the following referred to as FcRn), and provides an FcRn binding polypeptide comprising the sequence EX2 X3 X4 AX6 X7 EIRWLPNL X16X17 X18 QRX21 AFIX25 X26LX28 X29. The present disclosure also relates to the use of such an FcRn binding polypeptide as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US10323066B2
公开(公告)日：2019-06-18
申请号：US15510900
申请日：2015-09-17
Applicant: Affibody AB
Inventor： Lars Abrahmsén , Caroline Ekblad , Elin Gunneriusson , Torbjörn Gräslund , Johan Seijsing , John Löfblom , Malin Lindborg , Fredrik Frejd , Lindvi Gudmundsdotter
IPC: C07K14/31 , C07K14/00 , C07K14/735 , C07K14/74 , A61K38/00
Abstract: The present disclosure relates to dimers of engineered polypeptides having a binding affinity for the neonatal Fc receptor FcRn, and provides an FcRn binding dimer, comprising a first monomer unit, a second monomer unit and an amino acid linker, wherein the first and second monomer units each comprises an FcRn binding motif. The FcRn binding dimer binds FcRn with higher capacity compared to the first monomer unit or second monomer unit alone. The present disclosure also relates to the use of the FcRn binding dimer as an agent for modifying pharmacokinetic and pharmacodynamic properties and as a therapeutic agent.
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公开(公告)号：US10155792B2
公开(公告)日：2018-12-18
申请号：US14427102
申请日：2013-09-25
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Joachim Feldwisch , Kyong-Hoon Ahn
IPC: C07K14/195 , A61K38/00 , C07K14/315 , A61K47/48
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. In particular, the present invention relates to albumin binding polypeptides which have a high resistance to enzymatic cleavage. The disclosure provides an albumin binding polypeptide comprising an albumin binding motif, which motif consists of the amino acid sequence GVSDFYKKLI XaKAKTVEGVE ALKXbXcI (SEQ ID NO:29).
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Patent Agency Ranking
公开(公告)号：US20160108095A1
公开(公告)日：2016-04-21
申请号：US14955647
申请日：2015-12-01
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Lars Abrahmsen
IPC: C07K14/315 , A61K47/48
CPC classification number: C07K14/315 , A61K38/00 , A61K51/081 , C07K14/001 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/70 , Y02A50/473
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
Abstract translation: 本公开涉及对白蛋白具有结合亲和力的一类工程改造的多肽。 它还涉及利用这些和其它化合物在不同背景下结合白蛋白的新方法和用途，其中一些对于包括人在内的哺乳动物的疾病的治疗或诊断具有重要意义。
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公开(公告)号：US20210047372A1
公开(公告)日：2021-02-18
申请号：US16977625
申请日：2019-03-12
Applicant: AFFIBODY AB
Inventor： Caroline Ekblad , Elin Gunneriusson , Sophia Hober , Sarah Lindbo
Abstract: The disclosure provides a population of polypeptide variants based on a common scaffold, each polypeptide in the population comprising the scaffold amino acid sequence Xsc1AELDXsc2Xsc3GVG AXXIKXIXsc4XA XXVEXVQXXK QXILAX. The disclosure also provides methods for selecting and identifying polypeptides from the population, as well as such polypeptides themselves.
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公开(公告)号：US10329331B2
公开(公告)日：2019-06-25
申请号：US14955647
申请日：2015-12-01
Applicant: Affibody AB
Inventor： Caroline Ekblad , Lars Abrahmsen
IPC: C07K14/315 , C07K14/00 , A61K51/08 , A61K38/00
Abstract: The present disclosure relates to a class of engineered polypeptides having a binding affinity for albumin. It also relates to new methods and uses that exploit binding by these and other compounds to albumin in different contexts, some of which have significance for treatment or diagnosis of disease in mammals including humans.
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公开(公告)号：US20190031727A1
公开(公告)日：2019-01-31
申请号：US16157842
申请日：2018-10-11
Applicant: AFFIBODY AB
Inventor： David Bejker , Caroline Ekblad
Abstract: The present invention is within the field of administration of biopharmaceuticals. more specifically, the invention provides for oral administration of a compound comprising a moiety which confers a desired therapeutic activity; and a polypeptide moiety which binds to albumin.
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公开(公告)号：US20160009767A9
公开(公告)日：2016-01-14
申请号：US14385618
申请日：2013-03-15
Applicant: AFFIBODY AB
Inventor： David Bejker , Caroline Ekblad
IPC: C07K14/315 , C07K14/31 , C07K14/195 , C07K14/00 , A61K9/00
CPC classification number: C07K14/315 , A61K9/0053 , A61K38/00 , A61K47/50 , A61K47/643 , C07K14/00 , C07K14/195 , C07K14/31 , C07K2319/31
Abstract: The present invention is within the field of administration of biopharmaceuticals. More specifically, the invention provides for oral administration of a compound comprising a moiety which confers a desired therapeutic activity; and a polypeptide moiety which binds to albumin.
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