公开(公告)号：US20190135743A1

公开(公告)日：2019-05-09

申请号：US16099929

申请日：2017-05-09

Applicant: AGC INC. ,  NIPPON ZOKI PHARMACEUTICAL CO., LTD.

Inventor： Arata YASUDA ,  Yasushi MATSUMURA ,  Kazuyoshi SAWADA ,  Hiroyoshi NANBA ,  Kazuki TAGUCHI

IPC: C07C405/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12

Abstract: The present invention relates to a novel prostaglandin derivative having an alkynyl group on ω-chain, particularly, a novel prostaglandin derivative having a double bond at the 2-position and an alkynyl group on the ω-chain and a medicament containing the compound as an active ingredient.According to the present invention, a compound represented by the formula (1) or a pharmaceutically acceptable salt thereof; wherein each symbol is as defined in the present specification, or a cyclodextrin clathrate compound thereof, and a medicament containing the compound as an active ingredient, particularly, a medicament for the prophylaxis or treatment of a blood flow disorder associated with spinal canal stenosis or chronic arterial occlusion, can be provided.

公开(公告)号：US20190263746A1

公开(公告)日：2019-08-29

申请号：US16087369

申请日：2017-02-24

Applicant: AGC INC.

Inventor： Takashi AKIYA ,  Mitsugu KASAGAWA ,  Naoki ICHINOKAWA ,  Yu ONOZAKI ,  Satoshi KAWAGUCHI ,  Yusuke TOMIYORI ,  Arata YASUDA

IPC: C07C67/62 ,  C07C67/00 ,  C07C69/653 ,  C07C43/313

Abstract: The present invention provides a production method of α-fluoroacrylate ester, a composition containing a highly-pure fluorocyclopropane derivative and a composition containing highly-pure α-fluoroacrylate ester. The present invention relates to a method of producing a compound represented by the following formula (F), including subjecting a composition containing a compound represented by the following formula (A) to a purification treatment in the order of distillation and washing with an aqueous alkali solution to give a purified product containing a compound represented by the following formula (A), and subjecting the purified product to a thermal decomposition reaction, a composition containing a highly-pure compound represented by the following formula (A), and a composition containing a highly-pure compound represented by the following formula (F), wherein R may be the same or different and is a monovalent hydrocarbon group, and X is a halogen atom: